Expression of nuclear factor one A and -B in the olfactory bulb

Plachez, Celine, Cato, Kathleen, McLeay, Robert C., Heng, Yee Hsieh Evelyn, Bailey, Timothy L., Gronostajski, Richard M., Richards, Linda J., Puche, Adam C. and Piper, Michael (2012) Expression of nuclear factor one A and -B in the olfactory bulb. The Journal of Comparative Neurology, 520 14: 3135-3149. doi:10.1002/cne.23081

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Author Plachez, Celine
Cato, Kathleen
McLeay, Robert C.
Heng, Yee Hsieh Evelyn
Bailey, Timothy L.
Gronostajski, Richard M.
Richards, Linda J.
Puche, Adam C.
Piper, Michael
Title Expression of nuclear factor one A and -B in the olfactory bulb
Journal name The Journal of Comparative Neurology   Check publisher's open access policy
ISSN 0021-9967
Publication date 2012-10-01
Sub-type Article (original research)
DOI 10.1002/cne.23081
Open Access Status File (Author Post-print)
Volume 520
Issue 14
Start page 3135
End page 3149
Total pages 15
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
The nuclear factor one (NFI) family of transcription factors consists of four members in vertebrates, NFIA, NFIB, NFIC, and NFIX, which share a highly conserved N-terminal DNA-binding domain. NFI genes are widely expressed in the developing mouse brain, and mouse mutants lacking NFIA, NFIB, or NFIX exhibit developmental deficits in several areas, including the cortex, hippocampus, pons, and cerebellum. Here we analyzed the expression of NFIA and NFIB in the developing and adult olfactory bulb (OB), rostral migratory stream (RMS), and subventricular zone (SVZ). We found that NFIA and NFIB are expressed within these regions during embryonic and postnatal development and in the adult. Immunohistochemical analysis using cell-type-specific markers revealed that migrating neuroblasts in the adult brain express NFI transcription factors, as do astrocytes within the RMS and progenitor cells within the SVZ. Moreover, astrocytes within the OB express NFIA, whereas mitral cells within the OB express NFIB. Taken together these data show that NFIA and NFIB are expressed in both the developing and the adult OB and in the RMS and SVZ, indicative of a regulatory role for these transcription factors in the development of this facet of the olfactory system.
Keyword Rostral migratory stream
Olfactory bulb
Subventricular zone
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 13 Sep 2012, 01:39:05 EST by Dr Michael Piper on behalf of School of Biomedical Sciences