Zinc, vitamin A, and vitamin C status are associated with leptin concentrations and obesity in Mexican women: Results from a cross-sectional study

Patricia Garcia, Olga, Ronquillo, Dolores, del Carmen Caamano, Maria, Camacho, Mariela, Long, Kurt Zane and Rosado, Jorge L. (2012) Zinc, vitamin A, and vitamin C status are associated with leptin concentrations and obesity in Mexican women: Results from a cross-sectional study. Nutrition & Metabolism, 9 . doi:10.1186/1743-7075-9-59


Author Patricia Garcia, Olga
Ronquillo, Dolores
del Carmen Caamano, Maria
Camacho, Mariela
Long, Kurt Zane
Rosado, Jorge L.
Title Zinc, vitamin A, and vitamin C status are associated with leptin concentrations and obesity in Mexican women: Results from a cross-sectional study
Journal name Nutrition & Metabolism   Check publisher's open access policy
ISSN 1743-7075
Publication date 2012-06-01
Sub-type Article (original research)
DOI 10.1186/1743-7075-9-59
Open Access Status DOI
Volume 9
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Background: The prevalence of obesity among Mexican women is high and it could be related to micronutrient status. We evaluated in a cross-sectional study the associations of zinc and vitamins A, C and E concentrations with BMI, central adiposity, body fat and leptin concentration.

Methods: Women aged 37 ± 7.5 years (n = 580) from 6 rural communities in Mexico were evaluated. Anthropometric measurements included weight, height, waist and hip circumference. A fasting blood sample was taken for the analysis of glucose, lipid profile, leptin, zinc, and vitamins A, C and E. Body composition was determined by DEXA (Hologic Mod Explorer).

Results: The prevalence of overweight and obesity was 36% (BMI>25 Kg/m 2) and 44% (BMI>30 Kg/m 2), respectively. Prevalence of zinc and vitamins C and E deficiencies were similar in obese, overweight and normal weight women. No vitamin A deficiency was found. Vitamin C was negatively associated with BMI, waist-to-height ratio, and leptin concentrations (p<0.05). Vitamin A was positively associated with leptin (p<0.05). When stratifying by BMI, % body fat and waist circumference, high leptin concentrations were associated with lower zinc and lower vitamin C concentrations in women with obesity (p<0.05) and higher vitamin A concentrations in women without obesity (p<0.01). Vitamin E status was not associated with any markers of obesity.

Conclusion: Zinc and vitamins A and C are associated with obesity, adiposity and leptin concentration in women from rural Mexico, and may play an important role in fat deposition. The causality of these associations needs to be confirmed.
Keyword Micronutrient deficiencies
Obesity
Leptin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
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