Identification of novel markers of mouse fetal ovary development

Chen, Huijun, Palmer, James S., Thaigarajan, Rathi D., Dinger, Marcel E., Frampton, Emmanuelle, Chiu, Hansheng, Schulz, Alexandra, Spiller, Cassy, Grimmond, Sean M., Little, Melissa H., Koopman, Peter A. and Wilhelm, Ingrid D. (2012) Identification of novel markers of mouse fetal ovary development. PLoS One, 7 7: e41683.1-e41683.15. doi:10.1371/journal.pone.0041683

Author Chen, Huijun
Palmer, James S.
Thaigarajan, Rathi D.
Dinger, Marcel E.
Frampton, Emmanuelle
Chiu, Hansheng
Schulz, Alexandra
Spiller, Cassy
Grimmond, Sean M.
Little, Melissa H.
Koopman, Peter A.
Wilhelm, Ingrid D.
Title Identification of novel markers of mouse fetal ovary development
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2012-07-26
Sub-type Article (original research)
DOI 10.1371/journal.pone.0041683
Open Access Status DOI
Volume 7
Issue 7
Start page e41683.1
End page e41683.15
Total pages 15
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Formatted abstract
In contrast to the developing testis, molecular pathways driving fetal ovarian development have been difficult to characterise. To date no single master regulator of ovarian development has been identified that would be considered the female equivalent of Sry. Using a genomic approach we identified a number of novel protein-coding as well as non-coding genes that were detectable at higher levels in the ovary compared to testis during early mouse gonad development. We were able to cluster these ovarian genes into different temporal expression categories. Of note, Lrrc34 and AK015184 were detected in XX but not XY germ cells before the onset of sex-specific germ cell differentiation marked by entry into meiosis in an ovary and mitotic arrest in a testis. We also defined distinct spatial expression domains of somatic cell genes in the developing ovary. Our data expands the set of markers of early mouse ovary differentiation and identifies a classification of early ovarian genes, thus providing additional avenues with which to dissect this process.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Wed, 05 Sep 2012, 22:40:40 EST by Susan Allen on behalf of Institute for Molecular Bioscience