Sparse sampling methods in multidimensional NMR

Mobli, Mehdi, Maciejewski, Mark W., Schuyler, Adam D., Stern, Alan S. and Hoch, Jeffrey C. (2012) Sparse sampling methods in multidimensional NMR. Physical Chemistry Chemical Physics, 14 31: 10835-10843. doi:10.1039/c2cp40174f

Author Mobli, Mehdi
Maciejewski, Mark W.
Schuyler, Adam D.
Stern, Alan S.
Hoch, Jeffrey C.
Title Sparse sampling methods in multidimensional NMR
Journal name Physical Chemistry Chemical Physics   Check publisher's open access policy
ISSN 1463-9076
ISBN 978-1-60750-694-2
Publication date 2012-08-21
Year available 2012
Sub-type Article (original research)
DOI 10.1039/c2cp40174f
Open Access Status Not Open Access
Volume 14
Issue 31
Start page 10835
End page 10843
Total pages 9
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Language eng
Abstract Although the discrete Fourier transform played an enabling role in the development of modern NMR spectroscopy, it suffers from a well-known difficulty providing high-resolution spectra from short data records. In multidimensional NMR experiments, so-called indirect time dimensions are sampled parametrically, with each instance of evolution times along the indirect dimensions sampled via separate one-dimensional experiments. The time required to conduct multidimensional experiments is directly proportional to the number of indirect evolution times sampled. Despite remarkable advances in resolution with increasing magnetic field strength, multiple dimensions remain essential for resolving individual resonances in NMR spectra of biological macromolecues. Conventional Fourier-based methods of spectrum analysis limit the resolution that can be practically achieved in the indirect dimensions. Nonuniform or sparse data collection strategies, together with suitable non-Fourier methods of spectrum analysis, enable high-resolution multidimensional spectra to be obtained. Although some of these approaches were first employed in NMR more than two decades ago, it is only relatively recently that they have been widely adopted. Here we describe the current practice of sparse sampling methods and prospects for further development of the approach to improve resolution and sensitivity and shorten experiment time in multidimensional NMR. While sparse sampling is particularly promising for multidimensional NMR, the basic principles could apply to other forms of multidimensional spectroscopy.
Keyword Biochemistry & Molecular Biology
Biochemistry & Molecular Biology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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