Mammalian kidney development: Principles, progress, and projections

Little, Melissa H. and McMahon, Andrew P. (2012) Mammalian kidney development: Principles, progress, and projections. Cold Spring Harbor Perspectives in Biology, 4 5: 1-18. doi:10.1101/cshperspect.a008300

Author Little, Melissa H.
McMahon, Andrew P.
Title Mammalian kidney development: Principles, progress, and projections
Journal name Cold Spring Harbor Perspectives in Biology   Check publisher's open access policy
ISSN 1943-0264
Publication date 2012-05-01
Sub-type Article (original research)
DOI 10.1101/cshperspect.a008300
Open Access Status Not Open Access
Volume 4
Issue 5
Start page 1
End page 18
Total pages 1918
Place of publication Woodbury, NY United States
Publisher Cold Spring Harbor Laboratory Press
Language eng
Formatted abstract
The mammalian kidney is a vital organ with considerable cellular complexity and functional diversity. Kidney development is notable for requiring distinct but coincident tubulogenic processes involving reciprocal inductive signals between mesenchymal and epithelial progenitorcompartments.  Key molecular pathways mediating these interactions have been identified.  Further, advances in the analysis of gene expression and gene activity, coupled with a detailed knowledge of cell origins, are enhancing our understanding of kidney morphogenesis and unraveling the normal processes of postnatal repair and identifying disease-causing mechanisms.  This article focuses on recent insights into central regulatory processes governing organ assembly and renal disease, and predicts future directions for the field.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 96 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 104 times in Scopus Article | Citations
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Created: Thu, 23 Aug 2012, 19:33:32 EST by Susan Allen on behalf of Institute for Molecular Bioscience