Epigenetics and developmental programming of adult onset diseases

O'Sullivan, Lee, Little, Melissa H., Combes, Alexander N. and Moritz, Karen M. (2012) Epigenetics and developmental programming of adult onset diseases. Pediatric Nephrology, 27 12: 2175-2182. doi:10.1007/s00467-012-2108-x

Author O'Sullivan, Lee
Little, Melissa H.
Combes, Alexander N.
Moritz, Karen M.
Title Epigenetics and developmental programming of adult onset diseases
Journal name Pediatric Nephrology   Check publisher's open access policy
ISSN 0931-041X
Publication date 2012-02-02
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00467-012-2108-x
Open Access Status Not yet assessed
Volume 27
Issue 12
Start page 2175
End page 2182
Total pages 8
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract Maternal perturbations or sub-optimal conditions during development are now recognized as contributing to the onset of many diseases manifesting in adulthood. This "developmental programming" of disease has been explored using animal models allowing insights into the potential mechanisms involved. Impaired renal development, resulting in a low nephron number, has been identified as a common outcome that is likely to contribute to the development of hypertension in the offspring as adults. Changes in other organs and systems, including the heart and the hypothalamic-pituitary-adrenal axis, have also been found. Evidence has recently emerged suggesting that epigenetic changes may occur as a result of developmental programming and result in permanent changes in the expression patterns of particular genes. Such epigenetic modifications may be responsible not only for an increased susceptibility to disease for an individual, but indirectly for the establishment of a disease state in a subsequent generation. Further research in this field, particularly examination as to whether epigenetic changes to genes affecting kidney development do occur, are essential to understanding the underlying mechanisms of developmental programming of disease.
Keyword Epigenetic modification
Prenatal programming
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 02 February 2012

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 22 Aug 2012, 01:53:03 EST by Susan Allen on behalf of Institute for Molecular Bioscience