Discovery and applications of disulfide-rich cyclic peptides

Cemazar, M., Kwon, S., Mahatmanto, T., Ravipati, A. S. and Craik, David J. (2012) Discovery and applications of disulfide-rich cyclic peptides. Current Topics in Medicinal Chemistry, 12 14: 1534-1545. doi:10.2174/156802612802652484

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Author Cemazar, M.
Kwon, S.
Mahatmanto, T.
Ravipati, A. S.
Craik, David J.
Title Discovery and applications of disulfide-rich cyclic peptides
Journal name Current Topics in Medicinal Chemistry   Check publisher's open access policy
ISSN 1568-0266
Publication date 2012-07-17
Sub-type Article (original research)
DOI 10.2174/156802612802652484
Open Access Status Not Open Access
Volume 12
Issue 14
Start page 1534
End page 1545
Total pages 12
Place of publication Bussum, Netherlands
Publisher Bentham Science
Language eng
Abstract Cyclic peptides typically have much higher stability and improved biopharmaceutical properties over their linear counterparts. Our work focuses on the discovery of naturally occurring disulfide-rich cyclic peptides and their applications in drug design. These peptides provide a design basis for re-engineering natural acyclic peptides to improve their biopharmaceutical properties by chemically linking their termini. Here we describe examples of the discovery of the cyclotide family of peptides, their chemical re-engineering to introduce desired pharmaceutical activities, studies of their biopharmaceutical properties and applications of cyclization technologies to naturally occurring toxins, including conotoxins and scorpion toxins. In the case of the conotoxin Vc1.1, we produced an orally active peptide with potential for the treatment of neuropathic pain by cyclising the native peptide.In the case of the scorpion toxin chlorotoxin, a cyclised derivative had improved biopharmaceutical properties as a tumour imaging agent over the naturally occurring linear chlorotoxin. Ongoing chemical and structural studies of these classes of disulfide-rich peptides promise to increase their value for use in dissecting biological processes in plants and mammals while also providing leads to new classes of biopharmaceuticals.
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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Created: Thu, 02 Aug 2012, 01:16:02 EST by Susan Allen on behalf of Institute for Molecular Bioscience