Tumor lymphangiogenesis as a potential therapeutic target

Duong, Tam, Koopman, Peter A. and Francois, Mathias (2012) Tumor lymphangiogenesis as a potential therapeutic target. Journal of Oncology, 2012 . doi:10.1155/2012/204946


Author Duong, Tam
Koopman, Peter A.
Francois, Mathias
Title Tumor lymphangiogenesis as a potential therapeutic target
Journal name Journal of Oncology   Check publisher's open access policy
ISSN 1687-8450
1687-8469
Publication date 2012-02-16
Sub-type Article (original research)
DOI 10.1155/2012/204946
Open Access Status DOI
Volume 2012
Total pages 23
Place of publication New York, NY, United States
Publisher Hindawi Publishing Corporation
Language eng
Subject 2730 Oncology
Abstract Metastasis the spread of cancer cells to distant organs, is the main cause of death for cancer patients. Metastasis is often mediated by lymphatic vessels that invade the primary tumor, and an early sign of metastasis is the presence of cancer cells in the regional lymph node (the first lymph node colonized by metastasizing cancer cells from a primary tumor). Understanding the interplay between tumorigenesis and lymphangiogenesis (the formation of lymphatic vessels associated with tumor growth) will provide us with new insights into mechanisms that modulate metastatic spread. In the long term, these insights will help to define new molecular targets that could be used to block lymphatic vessel-mediated metastasis and increase patient survival. Here, we review the molecular mechanisms of embryonic lymphangiogenesis and those that are recapitulated in tumor lymphangiogenesis, with a view to identifying potential targets for therapies designed to suppress tumor lymphangiogenesis and hence metastasis.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article ID 204946

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 01 Aug 2012, 23:46:35 EST by Susan Allen on behalf of Institute for Molecular Bioscience