Retinal nerve fibre layer thinning associated with diabetic peripheral neuropathy

Shahidi, A. M., Sampson, G. P., Pritchard, N., Edwards, K., Vagenas, D., Russell, A. W., Malik, R. A. and Efron, N. (2012) Retinal nerve fibre layer thinning associated with diabetic peripheral neuropathy. Diabetic Medicine, 29 7: E106-E111. doi:10.1111/j.1464-5491.2012.03588.x


Author Shahidi, A. M.
Sampson, G. P.
Pritchard, N.
Edwards, K.
Vagenas, D.
Russell, A. W.
Malik, R. A.
Efron, N.
Title Retinal nerve fibre layer thinning associated with diabetic peripheral neuropathy
Journal name Diabetic Medicine   Check publisher's open access policy
ISSN 0742-3071
1464-5491
Publication date 2012-07-01
Sub-type Article (original research)
DOI 10.1111/j.1464-5491.2012.03588.x
Volume 29
Issue 7
Start page E106
End page E111
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Collection year 2013
Language eng
Formatted abstract
Aims: To investigate the relationship between retinal nerve fibre layer thickness and peripheral neuropathy in patients with Type 2 diabetes, particularly in those who are at higher risk of foot ulceration.

Methods: Global and sectoral retinal nerve fibre layer thicknesses were measured at 3.45mm diameter around the optic nerve head using optical coherence tomography (OCT). The level of neuropathy was assessed in 106 participants (82 with Type 2 diabetes and 24 healthy controls) using the 0-10 neuropathy disability score. Participants were stratified into four neuropathy groups: none (0-2), mild (3-5), moderate (6-8), and severe (9-10). A neuropathy disability score ≥6 was used to define those at higher risk of foot ulceration. Multivariable regression analysis was performed to assess the effect of neuropathy disability scores, age, disease duration and retinopathy on RNFL thickness.

Results: Inferior (but not global or other sectoral) retinal nerve fibre layer thinning was associated with higher neuropathy disability scores (P=0.03). The retinal nerve fibre layer was significantly thinner for the group with neuropathy disability scores ≥6 in the inferior quadrant (P<0.005). Age, duration of disease and retinopathy levels did not significantly influence retinal nerve fibre layer thickness. Control participants did not show any significant differences in thickness measurements from the group with diabetes and no neuropathy (P>0.24 for global and all sectors).

Conclusions: Inferior quadrant retinal nerve fibre layer thinning is associated with peripheral neuropathy in patients with Type 2 diabetes, and is more pronounced in those at higher risk of foot ulceration.
Keyword Diabetic peripheral neuropathy
Optical coherence tomography
Retinal nerve fibre layer thinning
Optical coherence tomography
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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