Vincristine: Can its therapeutic index be enhanced?

Moore, Andrew and Pinkerton, Ross (2009) Vincristine: Can its therapeutic index be enhanced?. Pediatric Blood and Cancer, 53 7: 1180-1187. doi:10.1002/pbc.22161


Author Moore, Andrew
Pinkerton, Ross
Title Vincristine: Can its therapeutic index be enhanced?
Journal name Pediatric Blood and Cancer   Check publisher's open access policy
ISSN 1545-5009
1545-5017
Publication date 2009-12-15
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/pbc.22161
Volume 53
Issue 7
Start page 1180
End page 1187
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Vincristine is one of the most widely used and more effective drugs in paediatric oncology. The dose-limiting toxicity of neuropathy, lack of proven neuroprotective measures and an incomplete understanding of the pharmacokinetics and pharmacogenetics of vincristine have limited its therapeutic potential. Recent advances in the understanding of vincristine pharmacokinetics and pharmacogenetics, and potential methods of preventing neurotoxicity are reviewed which could enable dose escalation and dose individualisation in order to enhance the therapeutic index.
Keyword Cancer pharmacology
Chemotherapy neurotoxicities
Pharmacogenetics
Pharmacokinetics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Thu, 12 Jul 2012, 21:16:47 EST by Andrew Moore on behalf of Child Health Research Centre