Refining clinical phenotypes by contrasting ethnically different populations with schizophrenia from Australia, India and Sarawak

McLean, Duncan, John, Sujit, Barrett, Robert, McGrath, John, Loa, Peter, Thara, Rangaswamy and Mowry, Bryan (2012) Refining clinical phenotypes by contrasting ethnically different populations with schizophrenia from Australia, India and Sarawak. Psychiatry Research, 196 2-3: 194-200. doi:10.1016/j.psychres.2011.12.027


Author McLean, Duncan
John, Sujit
Barrett, Robert
McGrath, John
Loa, Peter
Thara, Rangaswamy
Mowry, Bryan
Title Refining clinical phenotypes by contrasting ethnically different populations with schizophrenia from Australia, India and Sarawak
Journal name Psychiatry Research   Check publisher's open access policy
ISSN 0165-1781
1872-7123
Publication date 2012-04-30
Sub-type Article (original research)
DOI 10.1016/j.psychres.2011.12.027
Volume 196
Issue 2-3
Start page 194
End page 200
Total pages 7
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Language eng
Formatted abstract
We contrasted demographic and clinical characteristics in transethnic schizophrenia populations from Australia (n = 821), India (n = 520) and Sarawak, Malaysia (n = 298) and proposed cultural explanations for identified site differences. From these we aimed to identify candidate variables free from significant cultural confounding that are hence suitable for inclusion in genetic analyses. We observed five phenomena: (1) more individuals were living alone in Australia than India or Sarawak; (2) drug use was lower in India than Australia or Sarawak; (3) duration of untreated psychosis (DUP) was longer in India than Australia or Sarawak; (4) the rate of schizoaffective disorder was lower in India than Australia or Sarawak; and (5) age at psychosis onset (AAO) was older in Sarawak than Australia or India. We suggest that site differences for living arrangements, drug use and DUP are culturally confounded. The schizoaffective site difference likely results from measurement bias. The AAO site difference, however, has no obvious cultural or measurement bias explanation. Therefore, this may be an ideal candidate for use in genetic studies, given that genetic variants affecting AAO have already been proposed.
Keyword Psychotic disorders
Age of onset
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 11 Jul 2012, 02:28:15 EST by Debra McMurtrie on behalf of Queensland Brain Institute