Attentional Processing in C57BL/6J Mice Exposed to Developmental Vitamin D Deficiency

Harms, Lauren R., Turner, Karly M., Eyles, Darryl W., Young, Jared W., McGrath, John J. and Burne, Thomas H. J. (2012) Attentional Processing in C57BL/6J Mice Exposed to Developmental Vitamin D Deficiency. PLoS One, 7 4 Article No. ee35896: . doi:10.1371/journal.pone.0035896

Author Harms, Lauren R.
Turner, Karly M.
Eyles, Darryl W.
Young, Jared W.
McGrath, John J.
Burne, Thomas H. J.
Title Attentional Processing in C57BL/6J Mice Exposed to Developmental Vitamin D Deficiency
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2012-04-01
Sub-type Article (original research)
DOI 10.1371/journal.pone.0035896
Open Access Status DOI
Volume 7
Issue 4 Article No. ee35896
Total pages 10
Place of publication San Francisco CA , United States
Publisher Public Library of Science
Language eng
Formatted abstract
Epidemiological evidence suggests that Developmental Vitamin D (DVD) deficiency is associated with an increased risk of schizophrenia. DVD deficiency in mice is associated with altered behaviour, however there has been no detailed investigation of cognitive behaviours in DVD-deficient mice. The aim of this study was to determine the effect of DVD deficiency on a range of cognitive tasks assessing attentional processing in C57BL/6J mice. DVD deficiency was established by feeding female C57BL/6J mice a vitamin D-deficient diet from four weeks of age. After six weeks on the diet, vitamin D-deficient and control females were mated with vitamin D-normal males and upon birth of the pups, all dams were returned to a diet containing vitamin D. The adult offspring were tested on a range of cognitive behavioural tests, including the five-choice serial reaction task (5C-SRT) and five-choice continuous performance test (5C-CPT), as well as latent inhibition using a fear conditioning paradigm. DVD deficiency was not associated with altered attentional performance on the 5C-SRT. In the 5C-CPT DVD-deficient male mice exhibited an impairment in inhibiting repetitive responses by making more perseverative responses, with no changes in premature or false alarm responding. DVD deficiency did not affect the acquisition or retention of cued fear conditioning, nor did it affect the expression of latent inhibition using a fear conditioning paradigm. DVD-deficient mice exhibited no major impairments in any of the cognitive domains tested. However, impairments in perseverative responding in DVD-deficient mice may indicate that these animals have specific alterations in systems governing compulsive or reward-seeking behaviour.
Keyword Obsessive-Compulsive Disorder
Reaction Time Task
Latent Inhibition
Adult Rats
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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