Using bacteria to treat diseases

Caragata, Eric P. and Walker, Thomas (2012) Using bacteria to treat diseases. Expert Opinion On Biological Therapy, 12 6: 701-712. doi:10.1517/14712598.2012.677429


Author Caragata, Eric P.
Walker, Thomas
Title Using bacteria to treat diseases
Journal name Expert Opinion On Biological Therapy   Check publisher's open access policy
ISSN 1471-2598
1744-7682
Publication date 2012-06-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/14712598.2012.677429
Open Access Status
Volume 12
Issue 6
Start page 701
End page 712
Total pages 12
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Formatted abstract
Introduction:
Mosquito-borne diseases such as malaria and dengue fever result in significant morbidity and mortality in developing countries. Vector control is often the most effective strategy to prevent disease transmission and novel methods are required to complement existing insecticide-based strategies. Biological control uses natural predators or pathogens to kill mosquitoes or reduce their capacity to transmit disease. Bacteria such as Wolbachia have been proposed to have the potential to provide effective biological control of mosquitoes.

Areas covered:
A review of the potential role of bacteria in the control of mosquito-borne diseases highlighting the advantages and disadvantages of each strategy. In particular, a comprehensive summary of the progress made using the bacterial endosymbiont Wolbachia for dengue control.

Expert opinion:

Pathogenic bacteria such as Bti can be used to kill mosquito larvae and several endosymbiotic bacteria such as Asaia could be genetically transformed to alter the mosquito's ability to transmit pathogens. The endosymbiotic bacterium Wolbachia has been successfully introduced into the principal vector of dengue, Aedes aegypti, and induces a variety of phenotypic effects that are predicted to reduce dengue transmission. The release of Wolbachia-infected mosquitoes has been undertaken as part of preliminary trials to determine the applied use of this bacterium for mosquito-borne disease control.
Keyword Bacteria
Dengue
Malaria
Mosquitoes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Biological Sciences Publications
 
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