Calcium and cAMP levels interact to determine attraction versus repulsion in axon guidance

Forbes, Elizabeth M., Thompson, Andrew W., Yuan, Jiajia and Goodhill, Geoffrey J. (2012) Calcium and cAMP levels interact to determine attraction versus repulsion in axon guidance. Neuron, 74 3: 490-503. doi:10.1016/j.neuron.2012.02.035

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Forbes, Elizabeth M.
Thompson, Andrew W.
Yuan, Jiajia
Goodhill, Geoffrey J.
Title Calcium and cAMP levels interact to determine attraction versus repulsion in axon guidance
Journal name Neuron   Check publisher's open access policy
ISSN 0896-6273
Publication date 2012-05-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.neuron.2012.02.035
Open Access Status DOI
Volume 74
Issue 3
Start page 490
End page 503
Total pages 14
Place of publication Cambridge, MA, United States
Publisher Cell Press
Language eng
Abstract Correct guidance of axons to their targets depends on an intricate network of signaling molecules in the growth cone. Calcium and cAMP are two key regulators of whether axons are attracted or repelled by molecular gradients, but how these molecules interact to determine guidance responses remains unclear. Here, we constructed a mathematical model for the relevant signaling network, which explained a large range of previous biological data and made predictions for when axons will be attracted or repelled. We then confirmed these predictions experimentally, in particular showing that while small increases in cAMP levels promote attraction large increases do not, and that under some circumstances reducing cAMP levels promotes attraction. Together, these results show that a relatively simple mathematical model can quantitatively predict guidance decisions across a wide range of conditions, and that calcium and cAMP levels play a more complex role in these decisions than previously determined.
Keyword Neuronal growth cones
Nerve growth
Ca2+ signals
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 631532
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
Queensland Brain Institute Publications
Official 2013 Collection
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 31 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 11 Jun 2012, 02:07:11 EST by System User on behalf of Queensland Brain Institute