Review article: Part two: Goal-directed resuscitation - Which goals? Perfusion targets

Holley, Anthony, Lukin, William, Paratz, Jennifer, Hawkins, Tracey, Boots, Robert and Lipman, Jeffrey (2012) Review article: Part two: Goal-directed resuscitation - Which goals? Perfusion targets. Emergency Medicine Australasia, 24 2: 127-135. doi:10.1111/j.1742-6723.2011.01515.x


Author Holley, Anthony
Lukin, William
Paratz, Jennifer
Hawkins, Tracey
Boots, Robert
Lipman, Jeffrey
Title Review article: Part two: Goal-directed resuscitation - Which goals? Perfusion targets
Journal name Emergency Medicine Australasia   Check publisher's open access policy
ISSN 1742-6731
1742-6723
Publication date 2012-04-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1742-6723.2011.01515.x
Volume 24
Issue 2
Start page 127
End page 135
Total pages 9
Place of publication Richmond VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Abstract Haemodynamic targets, such as cardiac output, mean arterial blood pressure and central venous oxygen saturations, remain crude predictors of tissue perfusion and oxygen supply at a cellular level. Shocked patients may appear adequately resuscitated based on normalization of global vital signs, yet they are still experiencing occult hypoperfusion. If targeted resuscitation is employed, appropriate use of end-points is critical. In this review, we consider the value of directing resuscitation at the microcirculation or cellular level. Current technologies available include sublingual capnometry, video microscopy of the microcirculation and near-infrared spectroscopy providing a measure of tissue oxygenation, whereas base deficit and lactate potentially provide a surrogate measure of the adequacy of global perfusion. The methodology and evidence for these technologies guiding resuscitation are considered in this narrative review.
Keyword End-point
Goal directed
Perfusion
Resuscitation
Shock
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 29 May 2012, 09:37:56 EST by System User on behalf of Anaesthesiology and Critical Care - RBWH