Triheptanoin in acute mouse seizure models

Nicola, Thomas K., Willis, Sarah, Sweetman, Lawrence and Borges, Karin (2012) Triheptanoin in acute mouse seizure models. Epilepsy Research, 99 3: 312-317. doi:10.1016/j.eplepsyres.2011.12.013

Author Nicola, Thomas K.
Willis, Sarah
Sweetman, Lawrence
Borges, Karin
Title Triheptanoin in acute mouse seizure models
Journal name Epilepsy Research   Check publisher's open access policy
ISSN 0920-1211
Publication date 2012-05-01
Sub-type Article (original research)
DOI 10.1016/j.eplepsyres.2011.12.013
Open Access Status Not Open Access
Volume 99
Issue 3
Start page 312
End page 317
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Triheptanoin, the triglyceride of heptanoate, is used to treat certain hereditary metabolic diseases in USA because of its anaplerotic potential. In two chronic mouse seizure models this clear tasteless oil was found to be reproducibly anticonvulsant. Here we investigated the effects of triheptanoin feeding in C3H and CD1 mice using standard acute seizure models. Feeding 30–40% triheptanoin (caloric intake) consistently elevated blood propionyl-carnitines, but inconsistent anticonvulsant effects were observed in the fluorothyl, pentylenetetrazole and 6 Hz seizure models. A 2 mA consistent increase in the maximal electroshock threshold was found after 3 weeks of 35% triheptanoin feeding (p = 0.018). In summary, triheptanoin shows a unique anticonvulsant profile in seizure models, compared to other treatments that are in the clinic. Therefore, despite small and/or inconsistent effects of triheptanoin in acute seizure models, triheptanoin remains of interest as a potential add-on treatment for patients with medically refractory epilepsy.
Keyword Metabolism
Mouse seizure models
Maximal electroshock
6 Hz
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
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Created: Sat, 26 May 2012, 01:10:17 EST by Bacsweet Kaur on behalf of School of Biomedical Sciences