Nuclear factor I genes regulate neuronal migration

Heng, Yee Hsieh Evelyn, Barry, Guy, Richards, Linda J. and Piper, Michael (2012) Nuclear factor I genes regulate neuronal migration. NeuroSignals, 20 3: 159-167. doi:10.1159/000330651

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Author Heng, Yee Hsieh Evelyn
Barry, Guy
Richards, Linda J.
Piper, Michael
Title Nuclear factor I genes regulate neuronal migration
Journal name NeuroSignals   Check publisher's open access policy
ISSN 1424-862X
Publication date 2012-05-01
Year available 2012
Sub-type Article (original research)
DOI 10.1159/000330651
Open Access Status DOI
Volume 20
Issue 3
Start page 159
End page 167
Total pages 9
Place of publication Basel, Switzerland
Publisher Karger
Language eng
Abstract Neuronal migration plays a central role in the formation of the brain, and deficits in this process can lead to aberrant brain function and subsequent disease. Neuronal migration is a complex process that involves the interaction of the neuron with the surrounding environmental milieu, and as such involves both cell-intrinsic and cell-extrinsic mechanisms. Studies performed in rodent models to investigate the formation of brain structures have provided key insights into how neuronal migration is coordinated during development. Within the cerebral cortex, glutamatergic neurons derived from the cortical ventricular zone migrate radially into the cortical plate, whereas interneurons derived within the ventrally located ganglionic eminences migrate tangentially into the cortex. Within the embryonic cerebellum, cerebellar granule neuron progenitors migrate from the rhombic lip over the surface of the cerebellar anlage, before differentiating and migrating radially into the internal granule layer of the cerebellum perinatally. In this review, we focus on one family of proteins, the nuclear factor I transcription factors, and review our understanding of how these molecules contribute to the formation of the hippocampus and the cerebellum via the regulation of neuronal migration.
Keyword Neuronal migration
Nuclear factor I
Cerebral cortex
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Wed, 23 May 2012, 01:04:17 EST by Bacsweet Kaur on behalf of School of Biomedical Sciences