Relationship Between Mast-Cell Degranulation and Inflammation in the Oral Cavity

Walsh, LJ, Davis, MF, Xu, LJ and Savage, NW (1995) Relationship Between Mast-Cell Degranulation and Inflammation in the Oral Cavity. Journal of Oral Pathology & Medicine, 24 6: 266-272. doi:10.1111/j.1600-0714.1995.tb01180.x


Author Walsh, LJ
Davis, MF
Xu, LJ
Savage, NW
Title Relationship Between Mast-Cell Degranulation and Inflammation in the Oral Cavity
Journal name Journal of Oral Pathology & Medicine   Check publisher's open access policy
ISSN 0904-2512
Publication date 1995-07-01
Year available 1995
Sub-type Article (original research)
DOI 10.1111/j.1600-0714.1995.tb01180.x
Open Access Status Not yet assessed
Volume 24
Issue 6
Start page 266
End page 272
Total pages 7
Place of publication COPENHAGEN
Publisher MUNKSGAARD INT PUBL LTD
Language eng
Abstract Mast cells are granule-containing secretory cells which are distributed preferentially about the microvascular bed in oral mucosa. This work examined the contribution of mast cell mediators to inflammation in the oral cavity. Mast cells in oral tissues expressed the serine proteases, tryptase and chymase, with a minor subpopulation being chymase-negative. Mast cells contained the cytokine tumour necrosis factor-alpha (TNF) in their granules. Degranulation of mast cells was a consistent feature of inflammatory lesions (lichen planus, gingivitis, pulpitis, periapical inflammation). In lichen planus, intracellular stores of TNF were depleted, and expression of mRNA for TNF was upregulated, indicating ongoing production and release of the cytokine. The density of mast cells in tissue compartments was related to the level of expression of E-selectin, an endothelial adhesion molecule which is known to be induced in skin by TNF derived from degranulating mast cells. Further attention should be directed toward the role of mast cell products, particularly TNF, in inflammation in the oral cavity.
Keyword Endothelium
Inflammation
Mast Cells
Proteases
Tumor Necrosis Factor
Leukocyte Adhesion Molecule-1
Tumor-Necrosis-Factor
Langerhans Cells
Lichen-Planus
Expression
Localization
Gingivitis
Proteins
Tissue
Humans
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 48 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 61 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 22 May 2012, 22:04:06 EST by System User