Expression of the Cd54 (icam-1) and Cd11a (lfa-1) Adhesion Molecules in Oral Mucosal Inflammation

Verdickt, GM, Savage, NW, Dodd, NM and Walsh, LJ (1992) Expression of the Cd54 (icam-1) and Cd11a (lfa-1) Adhesion Molecules in Oral Mucosal Inflammation. Journal of Oral Pathology & Medicine, 21 2: 65-69. doi:10.1111/j.1600-0714.1992.tb00981.x


Author Verdickt, GM
Savage, NW
Dodd, NM
Walsh, LJ
Title Expression of the Cd54 (icam-1) and Cd11a (lfa-1) Adhesion Molecules in Oral Mucosal Inflammation
Journal name Journal of Oral Pathology & Medicine   Check publisher's open access policy
ISSN 0904-2512
Publication date 1992-02-01
Year available 1992
Sub-type Article (original research)
DOI 10.1111/j.1600-0714.1992.tb00981.x
Open Access Status Not yet assessed
Volume 21
Issue 2
Start page 65
End page 69
Total pages 5
Place of publication COPENHAGEN
Publisher MUNKSGAARD INT PUBL LTD
Language eng
Abstract Previous studies of chronic dermatoses have suggested that expression of the CD54 cell surface antigen (intercellular adhesion molecule-1, ICAM-1) by keratinocytes is a feature of chronic inflammation. However, whether such expression is a prerequisite for intraepithelial migration of lymphocytes is unclear. The present study evaluated the expression of CD54 and its ligand, CD11a (lymphocyte function-associated antigen, LFA-1) in oral lesions of lichen planus, recurrent aphthous stomatitis, secondary Sjogren's syndrome and traumatic ulceration using an immunoperoxidase technique. In 33 of 56 lesions examined, substantial numbers of CD11a+ cells were present within oral mucosal epithelium despite an absence of detectable keratinocyte CD54 antigen expression. Consequently, CD54/CD11a adhesion interactions may not be critical in the initiation of oral mucosal inflammation.
Keyword Adhesion Molecules
Icam-1
Lfa-1
Lichen Planus, Mouth Diseases
Sjogrens Syndrome
Function-Associated Antigen-1
Delayed-Hypersensitivity Reaction
Mononuclear Leukocytes
Complement Receptor
Interferon-Gamma
Langerhans Cells
T-Cell
Lymphocyte
Binding
Keratinocytes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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