Exploiting the behaviour of wild malaria vectors to achieve high infection with fungal biocontrol agents

Mnyone, Ladslaus L., Lyimo, Issa N., Lwetoijera, Dickson W., Mpingwa, Monica W., Nchimbi, Nuru, Hancock, Penelope A., Russell, Tanya L., Kirby, Matthew J., Takken, Willem and Koenraadt, Constantianus J. M. (2012) Exploiting the behaviour of wild malaria vectors to achieve high infection with fungal biocontrol agents. Malaria Journal, 11 87.1-87.11. doi:10.1186/1475-2875-11-87


Author Mnyone, Ladslaus L.
Lyimo, Issa N.
Lwetoijera, Dickson W.
Mpingwa, Monica W.
Nchimbi, Nuru
Hancock, Penelope A.
Russell, Tanya L.
Kirby, Matthew J.
Takken, Willem
Koenraadt, Constantianus J. M.
Total Author Count Override 10
Title Exploiting the behaviour of wild malaria vectors to achieve high infection with fungal biocontrol agents
Journal name Malaria Journal   Check publisher's open access policy
ISSN 1475-2875
Publication date 2012-03-01
Sub-type Article (original research)
DOI 10.1186/1475-2875-11-87
Open Access Status DOI
Volume 11
Start page 87.1
End page 87.11
Total pages 11
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2013
Language eng
Formatted abstract
Background
Control of mosquitoes that transmit malaria has been the mainstay in the fight against the disease, but alternative methods are required in view of emerging insecticide resistance. Entomopathogenic fungi are candidate alternatives, but to date, few trials have translated the use of these agents to field-based evaluations of their actual impact on mosquito survival and malaria risk. Mineral oil-formulations of the entomopathogenic fungi Metarhizium anisopliae and Beauveria bassiana were applied using five different techniques that each exploited the behaviour of malaria mosquitoes when entering, host-seeking or resting in experimental huts in a malaria endemic area of rural Tanzania.

Results

Survival of mosquitoes was reduced by 39-57% relative to controls after forcing upward house-entry of mosquitoes through fungus treated baffles attached to the eaves or after application of fungus-treated surfaces around an occupied bed net (bed net strip design). Moreover, 68 to 76% of the treatment mosquitoes showed fungal growth and thus had sufficient contact with fungus treated surfaces. A population dynamic model of malaria-mosquito interactions shows that these infection rates reduce malaria transmission by 75-80% due to the effect of fungal infection on adult mortality alone. The model also demonstrated that even if a high proportion of the mosquitoes exhibits outdoor biting
behaviour, malaria transmission was still significantly reduced.

Conclusions

Entomopathogenic fungi strongly affect mosquito survival and have a high predicted impact on malaria transmission. These entomopathogens represent a viable alternative for malaria control, especially if they are used as part of an integrated vector management strategy.
Keyword Insecticide-treated nets
Anopheles-Gambiae-S.S.
Metarhizium-Anisopliae
Entomopathogenic Fungi
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Public Health Publications
 
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