Investigating potential mechanisms of obesity by metabolomics

Xie, Baogang, Waters, Michael J. and Schirra, Horst Joachim (2012) Investigating potential mechanisms of obesity by metabolomics. Journal of Biomedicine and Biotechnology, 2012 4: 805683.1-805683.10. doi:10.1155/2012/805683

Author Xie, Baogang
Waters, Michael J.
Schirra, Horst Joachim
Title Investigating potential mechanisms of obesity by metabolomics
Journal name Journal of Biomedicine and Biotechnology   Check publisher's open access policy
ISSN 1110-7243
Publication date 2012-01-01
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1155/2012/805683
Open Access Status DOI
Volume 2012
Issue 4
Start page 805683.1
End page 805683.10
Total pages 10
Place of publication New York, NY, United States
Publisher Hindawi Publishing Corporation
Language eng
Abstract Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Metabolomics is an emerging analytical technique for systemic determination of metabolite profiles, which is useful for understanding the biochemical changes in obesity or related diseases both in individual organs and at the organism level. Increasingly, this technology has been applied to the study of obesity, complementing transcriptomics and/or proteomics analyses. Indeed, the alterations of metabolites in biofluids/tissues are direct indicators of variations in physiology or pathology. In this paper, we will examine the obesity-related alterations in significant metabolites that have been identified by metabolomics as well as their metabolic pathway associations. Issues concerning the screening of biologically significant metabolites related to obesity will also be discussed.
Keyword Biotechnology & Applied Microbiology
Medicine, Research & Experimental
Biotechnology & Applied Microbiology
Research & Experimental Medicine
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DP1096950
Institutional Status UQ
Additional Notes Article ID 805683

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 34 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 17 May 2012, 19:39:37 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging