Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography

Asanuma, Taketoshi, Doblas, Sabrina, Tesiram, Yasvir A., Saunders, Debra, Cranford, Rebecca, Yasui, Hironobu, Inanami, Osamu, Smith, Nataliya, Floyd, Robert A., Kotake, Yashige and Towner, Rheal A. (2008) Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography. Journal of Magnetic Resonance Imaging, 28 3: 574-587. doi:10.1002/jmri.21474


Author Asanuma, Taketoshi
Doblas, Sabrina
Tesiram, Yasvir A.
Saunders, Debra
Cranford, Rebecca
Yasui, Hironobu
Inanami, Osamu
Smith, Nataliya
Floyd, Robert A.
Kotake, Yashige
Towner, Rheal A.
Title Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography
Journal name Journal of Magnetic Resonance Imaging   Check publisher's open access policy
ISSN 1053-1807
1522-2586
Publication date 2008-09-01
Year available 2008
Sub-type Article (original research)
DOI 10.1002/jmri.21474
Open Access Status Not Open Access
Volume 28
Issue 3
Start page 574
End page 587
Total pages 14
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Purpose: To apply fiber tractography to assess the effect of a possible antiglioma drug, phenyl N-tert-butyl nitrone (PBN), on glioma-affected neuronal fibers. The fiber tractography method was able to differentiate between different tumor types, such as the C6 and F98 rat glioma models.
Materials and Methods: C6 or F98 cells were intracranially injected into the cortex of male Fischer 344 rats. PBN treatment was initiated before or after cell implantation. Tumor growth was monitored with diffusion tensor imaging (DTI) and fiber tractography using diffusion-weighting gradients in 30 noncolinear directions.
Results: Although proton density-weighted (PDw) and T2-weighted (T2w) images did not show any difference between C6 and F98 gliomas without edema, the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps were able to discriminate between these two tumor models. Fiber tractography was used to visualize C6 glioma-induced ischemia of tumor-surrounding tissues, whereas F98 glioma was found to infiltrate and penetrate into the corpus callosum (CC). During glioma growth, neuronal fibers were found to disappear at the border regions between the tumor and surrounding tissues. PBN treatment was shown to inhibit glioma growth with accompanying changes in the surrounding tissue.
Conclusion: By noninvasively monitoring the degree of neuronal fiber integrity and connectivity with the use of neuronal fiber tractography, we were able to evaluate the protective effect of PBN against invasive glioma growth in rat brains. PBN provided protection of the neuronal fibers against tumor-induced ischemia and tumor invasion.
Keyword MRI
Diffusion tensor imaging
Fiber tractography
Neuronal fiber
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID fMRI-002
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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Created: Tue, 15 May 2012, 01:44:25 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging