A genome-wide association study of tick burden and milk composition in cattle

Turner, Lex B., Harrison, Blair E., Bunch, Rowan J., Neto, Laercio R., Li, Yutao and Barendse, William (2010) A genome-wide association study of tick burden and milk composition in cattle. Animal Production Science, 50 4: 235-245. doi:10.1071/AN09135

Author Turner, Lex B.
Harrison, Blair E.
Bunch, Rowan J.
Neto, Laercio R.
Li, Yutao
Barendse, William
Title A genome-wide association study of tick burden and milk composition in cattle
Journal name Animal Production Science   Check publisher's open access policy
ISSN 1836-0939
Publication date 2010-01-01
Sub-type Article (original research)
DOI 10.1071/AN09135
Volume 50
Issue 4
Start page 235
End page 245
Total pages 11
Place of publication Collingwood, Vic., Australia
Publisher CSIRO Publishing
Language eng
Formatted abstract
To study the genetic basis of tick burden and milk production and their interrelationship, we collected a sample of 1961 cattle with multiple tick counts from northern Australia of which 973 had dairy production data in the Australian Dairy Herd Information Service database. We calculated heritabilities, genetic and phenotypic correlations for these traits and showed a negative relationship between tick counts and milk and milk component yield. Tests of polymorphisms of four genes associated with milk yield, ABCG2, DGAT1, GHR and PRLR, showed no statistically significant effect on tick burden but highly significant associations to milk component yield in these data and we confirmed separate effects for GHR and PRLR on bovine chromosome 20. To begin to identify some of the molecular genetic bases for these traits, we genotyped a sample of 189 of these cattle for 7397 single nucleotide polymorphisms in a genome-wide association study. Although the allele effects for adjusted milk fat and protein yield were highly correlated (r = 0.66), the correlations of allele effects of these milk component yields and tick burden were small (|r| ≤ 0.10). These results agree in general with the phenotypic correlations between tick counts and milk component yield and suggest that selection on markers for tick burden or milk component yield may have no undesirable effect on the other trait.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
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