Outcomes in sinonasal mucosal melanoma

Martin, Jarad M., Porceddu, Sandro, Weih, LeAnn, Corry, June and Peters, Lester J. (2004) Outcomes in sinonasal mucosal melanoma. ANZ Journal of Surgery, 74 10: 838-842. doi:10.1111/j.1445-1433.2004.03185.x


Author Martin, Jarad M.
Porceddu, Sandro
Weih, LeAnn
Corry, June
Peters, Lester J.
Title Outcomes in sinonasal mucosal melanoma
Journal name ANZ Journal of Surgery   Check publisher's open access policy
ISSN 1445-1433
1445-2197
Publication date 2004-10-01
Year available 2004
Sub-type Article (original research)
DOI 10.1111/j.1445-1433.2004.03185.x
Open Access Status Not Open Access
Volume 74
Issue 10
Start page 838
End page 842
Total pages 5
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell
Language eng
Formatted abstract
Background: The present paper assesses treatment outcomes in a series of 20 patients with sinonasal mucosal melanoma (SNMM) over 11 years.

Methods:
All patients who presented to a single institution between 1991 and 2002 with a diagnosis of SNMM had their treatment reviewed and outcomes determined.

Results:
Twenty patients presented to our institution with SNMM over the study period. No cervical node or metastatic involvement was detected at presentation. The most common site of involvement was the nasal cavity (17/20). The majority of patients received initial surgery followed by radiotherapy (15/20). At the completion of treatment 14 patients had no disease evident. The median time to failure in these patients was 12 months. Of these patients 10 relapsed, including six who had metastatic failure only. Fifteen patients died due to disease. Median overall survival was 17 months, with a 2-year overall survival of 23%. In univariate analysis, patients with advanced tumours (T3-4) had a 4.3 times greater risk of dying than patients with early tumours (T1-2).

Conclusions:
Patients with SNMM have poor outcomes with conventional therapy. Full staging prior to treatment is recommended. Aggressive treatment carrying significant morbidity is justified only for patients with early stage disease.
Keyword Head and neck neoplasms
Melanoma
Mucous membrane
Radiotherapy
Surgery
Treatment outcome
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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