Effects of stress, mimicked by administration of corticosterone in drinking water, on the expression of chicken cytokine and chemokine genes in lymphocytes

Shini, S. and Kaiser, P. (2009) Effects of stress, mimicked by administration of corticosterone in drinking water, on the expression of chicken cytokine and chemokine genes in lymphocytes. Stress, 12 5: 388-399. doi:10.1080/10253890802526894


Author Shini, S.
Kaiser, P.
Title Effects of stress, mimicked by administration of corticosterone in drinking water, on the expression of chicken cytokine and chemokine genes in lymphocytes
Journal name Stress   Check publisher's open access policy
ISSN 1025-3890
1607-8888
Publication date 2009-09-01
Sub-type Article (original research)
DOI 10.1080/10253890802526894
Open Access Status Not yet assessed
Volume 12
Issue 5
Start page 388
End page 399
Total pages 12
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Subject 1314 Physiology
3206 Neuropsychology and Physiological Psychology
2807 Endocrine and Autonomic Systems
2738 Psychiatry and Mental health
2802 Behavioral Neuroscience
Abstract In this study, we identify molecular mediators that participate in the regulation of the immune response during corticosterone-induced stress in chickens. At 7 weeks of age, 120 chickens were exposed for 1 week to corticosterone treatment. Cytokine and chemokine mRNA expression levels were evaluated in peripheral blood and splenic lymphocytes. Expression levels of interleukin (IL)-1β, IL-6, IL-18 and transforming growth factor (TGF)-β4 mRNA were significantly up-regulated in lymphocytes 3 h after first treatment with corticosterone. TGF-β4 and IL-18 remained elevated 1 week post-initial treatment. Compared with controls, corticosterone-treated birds showed greater expression levels of chemokine (CC) mRNA, particularly for CCLi2, CCL5 (RANTES), CCL16 and CXCLi1, in peripheral and splenic lymphocytes 3 h post-initial exposure. CCLi2 mRNA was highly expressed in splenocytes at all time-points. Administration of corticosterone significantly increased circulating corticosterone concentrations and decreased total lymphocyte counts at 3, 24 h and 1 week post-initiation of corticosterone treatment. There was a positive correlation between plasma corticosterone concentrations and CCL5 and CCL16 mRNA at 3 h post-initial administration. At 1 week post-initial treatment, corticosterone concentrations correlated positively with CCL5 and negatively with IL-18 mRNA level. Conditions associated with significant changes in corticosterone levels might therefore affect the immune response by increasing pro-inflammatory responses, leading to potential modulation of the Th1/Th2 balance.
Keyword Chemokine
Chicken
Corticosterone
Cytokine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
 
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Created: Tue, 03 Apr 2012, 22:25:34 EST by Shaniko Shini on behalf of School of Veterinary Science