Prevalence of abnormal ankle-brachial index among individuals with low or intermediate framingham risk scores

Dhangana, Rajoo, Murphy, Timothy P., Coll, Joseph R., Ahn, Sun H., Zafar, Abdul M., Qadeer, Fathima F. and Hiatt, William R. (2011) Prevalence of abnormal ankle-brachial index among individuals with low or intermediate framingham risk scores. Journal of Vascular and Interventional Radiology, 22 8: 1077-1082. doi:10.1016/j.jvir.2011.04.008

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Author Dhangana, Rajoo
Murphy, Timothy P.
Coll, Joseph R.
Ahn, Sun H.
Zafar, Abdul M.
Qadeer, Fathima F.
Hiatt, William R.
Title Prevalence of abnormal ankle-brachial index among individuals with low or intermediate framingham risk scores
Journal name Journal of Vascular and Interventional Radiology   Check publisher's open access policy
ISSN 1051-0443
1535-7732
Publication date 2011-08-01
Sub-type Article (original research)
DOI 10.1016/j.jvir.2011.04.008
Volume 22
Issue 8
Start page 1077
End page 1082
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
Purpose

To determine the prevalence of an abnormal ankle-brachial index (ABI) among subjects not considered to be at high risk for cardiovascular disease (CVD) based on the Framingham Risk Score (FRS).

Materials and Methods


Data from the Population-Based Examinations to Determine Ankle-brachiaL index (PEDAL) Study (2007–2009), a cross-sectional study at 23 U.S. sites, in conjunction with Legs for Life, a national ABI screening program, were analyzed. This study includes data from 822 participants (average age 64.3 years ± 11.6, 69.7% women, 89.7% non-Hispanic white) without known CVD or diabetes, who were screened for peripheral artery disease (PAD) with an ABI and for whom all FRS variables were available. Participants' 10-year coronary heart disease (CHD) risk was estimated from the FRS, and three risk categories were defined: low (< 10%), intermediate (10%–19%), and high (≥ 20%). ABI < 0.90 or > 1.4 in either leg was considered abnormal.

Results

The prevalence of abnormal ABI was 14.2% (95%confidence interval [CI] 11.9%–16.8%). According to the FRS, 463 (56.3%) participants were at low risk, 212 (25.8%) were at intermediate risk, and 147 (17.9%) were at high risk. Among participants with a low FRS (n = 463; without CVD or diabetes or both) and an intermediate FRS (n = 212; without CVD or diabetes or both), 12.3% and 12.2% had an abnormal ABI.

Conclusions


The prevalence of abnormal ABI, a CHD equivalent, is high among individuals not identified as high risk by conventional Framingham-based risk assessment.
Keyword Coronary-heart-disease
Peripheral arterial-disease
Cardiovascular-disease
Mortality
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
 
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