Neurochemical enhancement of conscious error awareness

Hester, Robert, Nandam, L. Sanjay, O'Connell, Redmond G., Wagner, Jo, Strudwick, Mark, Nathan, Pradeep J., Mattingley, Jason B. and Bellgrove, Mark A. (2012) Neurochemical enhancement of conscious error awareness. Journal of Neuroscience, 32 8: 2619-2627. doi:10.1523/JNEUROSCI.4052-11.2012

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Author Hester, Robert
Nandam, L. Sanjay
O'Connell, Redmond G.
Wagner, Jo
Strudwick, Mark
Nathan, Pradeep J.
Mattingley, Jason B.
Bellgrove, Mark A.
Title Neurochemical enhancement of conscious error awareness
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2012-02-01
Year available 2012
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.4052-11.2012
Open Access Status File (Author Post-print)
Volume 32
Issue 8
Start page 2619
End page 2627
Total pages 9
Place of publication Washington, DC, United States
Publisher Society for Neuroscience
Language eng
Abstract How the brain monitors ongoing behavior for performance errors is a central question of cognitive neuroscience. Diminished awareness of performance errors limits the extent to which humans engage in corrective behavior and has been linked to loss of insight in a number of psychiatric syndromes (e.g., attention deficit hyperactivity disorder, drug addiction). These conditions share alterations in monoamine signaling that may influence the neural mechanisms underlying error processing, but our understanding of the neurochemical drivers of these processes is limited.Weconducted a randomized, double-blind, placebo-controlled, cross-over design of the influence of methylphenidate, atomoxetine, and citalopram on error awareness in 27 healthy participants. The error awareness task, a go/no-go response inhibition paradigm, was administered to assess the influence of monoaminergic agents on performance errors during fMRI data acquisition. A single dose of methylphenidate, but not atomoxetine or citalopram, significantly improved the ability of healthy volunteers to consciously detect performance errors. Furthermore, this behavioral effect was associated with a strengthening of activation differences in the dorsal anterior cingulate cortex and inferior parietal lobe during the methylphenidate condition for errors made with versus without awareness. Our results have implications for the understanding of the neurochemical underpinnings of performance monitoring and for the pharmacological treatment of a range of disparate clinical conditions that are marked by poor awareness of errors.
Keyword Attention-Deficit/hyperactivity Disorder
Traumatic Brain-Injury
International Neuropsychiatric Interview
Event-Related Fmri
Prefrontal Cortex
Cingulate Cortex
Cognitive Function
Cocaine Addiction
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DP0770337
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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