Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

Lee, S. Hong, DeCandia, Teresa R., Ripke, Stephan, Yang, Jian, Sullivan, Patrick F ., Goddard, Michael E ., Keller, Matthew C ., Visscher, Peter M ., Wray, Naomi R., Schizophrenia Psychiat Genome-Wide, Int Schizophrenia Consortium ISC, Mol Genetics Schizophrenia and Mowry, Bryan (2012) Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nature Genetics, 44 3: 247-250. doi:10.1038/ng.1108

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ271557_OA.pdf Full text (open access) application/pdf 634.07KB 0

Author Lee, S. Hong
DeCandia, Teresa R.
Ripke, Stephan
Yang, Jian
Sullivan, Patrick F .
Goddard, Michael E .
Keller, Matthew C .
Visscher, Peter M .
Wray, Naomi R.
Schizophrenia Psychiat Genome-Wide
Int Schizophrenia Consortium ISC
Mol Genetics Schizophrenia
Mowry, Bryan
Title Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2012-03-01
Year available 2012
Sub-type Article (original research)
DOI 10.1038/ng.1108
Open Access Status File (Author Post-print)
Volume 44
Issue 3
Start page 247
End page 250
Total pages 4
Place of publication Basingstoke, Hamps, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 x 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 x 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.
Formatted abstract
Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10 -8), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10 8). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.
Keyword Multiple Rare Alleles
Complex Trait
Human Height
Disease
Association
Variants
Twin
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 389892
DP0770096
MH085812
480-05-003
Institutional Status UQ
Additional Notes Published online 19 February 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 277 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 294 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 26 Mar 2012, 22:04:41 EST by System User on behalf of Queensland Brain Institute