Serum 25-Hydroxyvitamin D, Calcium Intake, and Risk of Type 2 Diabetes After 5 Years: Results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study)

Gagnon, Claudia, Lu, Zhong X., Magliano, Dianna J., Dunstan, David W., Shaw, Jonathan E., Zimmet, Paul Z., Sikaris, Ken, Grantham, Narelle, Ebeling, Peter R. and Daly, Robin M. (2011) Serum 25-Hydroxyvitamin D, Calcium Intake, and Risk of Type 2 Diabetes After 5 Years: Results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study). Diabetes Care, 34 5: 1133-1138. doi:10.2337/dc10-2167


Author Gagnon, Claudia
Lu, Zhong X.
Magliano, Dianna J.
Dunstan, David W.
Shaw, Jonathan E.
Zimmet, Paul Z.
Sikaris, Ken
Grantham, Narelle
Ebeling, Peter R.
Daly, Robin M.
Title Serum 25-Hydroxyvitamin D, Calcium Intake, and Risk of Type 2 Diabetes After 5 Years: Results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study)
Journal name Diabetes Care   Check publisher's open access policy
ISSN 0149-5992
1935-5548
Publication date 2011-05-01
Sub-type Article (original research)
DOI 10.2337/dc10-2167
Open Access Status DOI
Volume 34
Issue 5
Start page 1133
End page 1138
Total pages 6
Place of publication Alexandria, VA, United States
Publisher American Diabetes Association
Language eng
Formatted abstract
OBJECTIVE—To examine whether serum 25-hydroxyvitamin D (25OHD) and dietary calcium predict incident type 2 diabetes and insulin sensitivity.
RESEARCH DESIGNANDMETHODS—A total of 6,537 of the 11,247 adults evaluated
in 1999–2000 in the AustralianDiabetes,Obesity and Lifestyle (AusDiab) study, returned for oral glucose tolerance test (OGTT) in 2004–2005. We studied those without diabetes who had complete data at baseline (n = 5,200;mean age 51 years; 55%were women; 92% were Europids). Serum 25OHD and energy-adjusted calcium intake (food frequency questionnaire) were assessed at baseline. Logistic regression was used to evaluate associations between serum 25OHD and dietary calcium on 5-year incidence of diabetes (diagnosed by OGTT) and insulin sensitivity (homeostasis model assessment of insulin sensitivity [HOMA-S]), adjusted for multiple potential confounders, including fasting plasma glucose (FPG).
RESULTS—During the 5-year follow-up, 199 incident cases of diabeteswere diagnosed. Those who developed diabetes had lower serum 25OHD (mean 58 vs. 65 nmol/L; P , 0.001) and calcium intake (mean 881 vs. 923 mg/day; P = 0.03) compared with those who remained free of diabetes. Each 25 nmol/L increment in serum25OHD was associated with a 24%reduced risk of diabetes (odds ratio 0.76 [95% CI 0.63–0.92]) after adjusting for age, waist circumference, ethnicity, season, latitude, smoking, physical activity, family history of diabetes, dietary magnesium, hypertension, serum triglycerides, and FPG. Dietary calcium intake was not associated with reduced diabetes risk. Only serum 25OHD was positively and independently associated with HOMA-S at 5 years.
CONCLUSIONS—Higher serum 25OHD levels, but not higher dietary calcium, were associated with a significantly reduced risk of diabetes in Australian adult men and women.
Keyword Placebo-controlled Trial
Vitamin-d
Insulin-resistance
Women
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Received 17 November 2010 and accepted 18 February 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Public Health Publications
 
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Created: Fri, 23 Mar 2012, 01:06:00 EST by Geraldine Fitzgerald on behalf of School of Public Health