Growth hormone responsive neural precursor cells reside within the adult mammalian brain

Blackmore, Daniel G., Reynolds, Brent A., Golmohammadi, Mohammad G., Large, Beatrice, Aguilar, Roberto M., Haro, Luis, Waters, Michael J. and Rietze, Rodney L. (2012) Growth hormone responsive neural precursor cells reside within the adult mammalian brain. Scientific Reports, 2 250.1-250.10. doi:10.1038/srep00250

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Author Blackmore, Daniel G.
Reynolds, Brent A.
Golmohammadi, Mohammad G.
Large, Beatrice
Aguilar, Roberto M.
Haro, Luis
Waters, Michael J.
Rietze, Rodney L.
Title Growth hormone responsive neural precursor cells reside within the adult mammalian brain
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2012-01-01
Sub-type Article (original research)
DOI 10.1038/srep00250
Open Access Status DOI
Volume 2
Start page 250.1
End page 250.10
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract The detection of growth hormone (GH) and its receptor in germinal regions of the mammalian brain prompted our investigation of GH and its role in the regulation of endogenous neural precursor cell activity. Here we report that the addition of exogenous GH significantly increased the expansion rate in long-term neurosphere cultures derived from wild-type mice, while neurospheres derived from GH null mice exhibited a reduced expansion rate. We also detected a doubling in the frequency of large (i.e. stem cell-derived) colonies for up to 120 days following a 7-day intracerebroventricular infusion of GH suggesting the activation of endogenous stem cells. Moreover, gamma irradiation induced the ablation of normally quiescent stem cells in GH-infused mice, resulting in a decline in olfactory bulb neurogenesis. These results suggest that GH activates populations of resident stem and progenitor cells, and therefore may represent a novel therapeutic target for age-related neurodegeneration and associated cognitive decline.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # 250

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
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