The Early Prevention of Obesity in Children (EPOCH) Collaboration - an individual patient data prospective meta-analysis

Askie, Lisa M., Baur, Louise A., Campbell, Karen, Daniels, Lynne A., Hesketh, Kylie, Magarey, Anthea, Mihrshahi, Seema, Rissel, Chris, Simes, John, Taylor, Barry, Taylor, Rachael, Voysey, Merryn, Wen, Li M. and EPOCH Collaboration (2010) The Early Prevention of Obesity in Children (EPOCH) Collaboration - an individual patient data prospective meta-analysis. BMC Public Health, 10 5: 728.1-728.8. doi:10.1186/1471-2458-10-728

Author Askie, Lisa M.
Baur, Louise A.
Campbell, Karen
Daniels, Lynne A.
Hesketh, Kylie
Magarey, Anthea
Mihrshahi, Seema
Rissel, Chris
Simes, John
Taylor, Barry
Taylor, Rachael
Voysey, Merryn
Wen, Li M.
EPOCH Collaboration
Title The Early Prevention of Obesity in Children (EPOCH) Collaboration - an individual patient data prospective meta-analysis
Journal name BMC Public Health   Check publisher's open access policy
ISSN 1471-2458
Publication date 2010-11-01
Sub-type Article (original research)
DOI 10.1186/1471-2458-10-728
Open Access Status DOI
Volume 10
Issue 5
Start page 728.1
End page 728.8
Total pages 8
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Abstract We performed an individual patient data meta-analysis to assess the possible benefits and harms of statin therapy in adults with acute respiratory distress syndrome (ARDS) and to investigate effects in specific ARDS subgroups.
Formatted abstract
Background: Efforts to prevent the development of overweight and obesity have increasingly focused early in the life course as we recognise that both metabolic and behavioural patterns are often established within the first few years of life. Randomised controlled trials (RCTs) of interventions are even more powerful when, with forethought, they are synthesised into an individual patient data (IPD) prospective meta-analysis (PMA). An IPD PMA is a unique research design where several trials are identified for inclusion in an analysis before any of the individual trial results become known and the data are provided for each randomised patient. This methodology minimises the publication and selection bias often associated with a retrospective meta-analysis by allowing hypotheses, analysis methods and selection criteria to be specified a priori.
Methods/Design: The Early Prevention of Obesity in CHildren (EPOCH) Collaboration was formed in 2009. The main objective of the EPOCH Collaboration is to determine if early intervention for childhood obesity impacts on body mass index (BMI) z scores at age 18-24 months. Additional research questions will focus on whether early intervention has an impact on children's dietary quality, TV viewing time, duration of breastfeeding and parenting styles. This protocol includes the hypotheses, inclusion criteria and outcome measures to be used in the IPD PMA. The sample size of the combined dataset at final outcome assessment (approximately 1800 infants) will allow greater precision when exploring differences in the effect of early intervention with respect to pre-specified participant- and intervention-level characteristics.
Discussion: Finalisation of the data collection procedures and analysis plans will be complete by the end of 2010. Data collection and analysis will occur during 2011-2012 and results should be available by 2013.
Keyword ALI
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID MC_G1002460
Institutional Status Non-UQ
Additional Notes Study protocol. Article # 728.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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