No association of candidate genes with cannabis use in a large sample of Australian twin families

Verweij, Karin J. H., Zietsch, Brendan P., Liu, Jimmy Z., Medland, Sarah E., Lynskey, Michael T., Madden, Pamela A. F., Agrawal, Arpana, Montgomery, Grant W., Heath, Andrew C. and Martin, Nicholas G. (2012) No association of candidate genes with cannabis use in a large sample of Australian twin families. Addiction Biology, 17 3: 687-690. doi:10.1111/j.1369-1600.2011.00320.x


Author Verweij, Karin J. H.
Zietsch, Brendan P.
Liu, Jimmy Z.
Medland, Sarah E.
Lynskey, Michael T.
Madden, Pamela A. F.
Agrawal, Arpana
Montgomery, Grant W.
Heath, Andrew C.
Martin, Nicholas G.
Title No association of candidate genes with cannabis use in a large sample of Australian twin families
Journal name Addiction Biology   Check publisher's open access policy
ISSN 1355-6215
1369-1600
Publication date 2012-05-01
Year available 2011
Sub-type Article (original research)
DOI 10.1111/j.1369-1600.2011.00320.x
Volume 17
Issue 3
Start page 687
End page 690
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Language eng
Formatted abstract
While there is solid evidence that cannabis use is heritable, attempts to identify genetic influences at the molecular level have yielded mixed results. Here, a large twin family sample (n = 7452) was used to test for association between 10 previously reported candidate genes and lifetime frequency of cannabis use using a gene-based association test. None of the candidate genes reached even nominal significance (P < 0.05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false-positive findings in previous studies.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 20 April 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Psychology Publications
 
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Created: Mon, 19 Mar 2012, 02:30:25 EST by Mrs Alison Pike on behalf of School of Psychology