Genome analysis of the platypus reveals unique signatures of evolution

Warren, W. C., Hillier, L. W., Graves, J. A. M., Birney, E., Ponting, C. P., Grutzner, F., Belov, K., Miller, W., Clarke, L., Chinwalla, A. T., Yang, S. P., Heger, A., Locke, D. P., Miethke, P., Waters, P. D., Veyrunes, F., Fulton, L., Fulton, B., Graves, T., Wallis, J., Puente, X. S., Lopez-Otin, C., Ordonez, G. R., Eichler, E. E., Chen, L., Cheng, Z., Deakin, J. E., Alsop, A., Thompson, K., Kirby, P., Papenfuss, A. T., Wakefield, M. J., Olender, T., Lancet, D., Huttley, G. A., Smit, A. F. A., Pask, A., Temple-Smith, P., Batzer, M. A., Walker, J. A., Konkel, M. K., Harris, R. S., Whittington, C. M., Wong, E. S. W., Gemmell, N. J., Buschiazzo, E., Jentzsch, I. M. V., Merkel, A., Schmitz, J., Zemann, A., Churakov, G., Kriegs, J. O., Brosius, J., Murchison, E. P., Sachidanandam, R., Smith, C., Hannon, G. J., Tsend-Ayush, E., McMillan, D., Attenborough, R., Rens, W., Ferguson-Smith, M., Lefevre, C. M., Sharp, J. A., Nicholas, K. R., Ray, D. A., Kube, M., Reinhardt, R., Pringle, T. H., Taylor, J., Jones, R. C., Nixon, B., Dacheux, J. L., Niwa, H., Sekita, Y., Huang, X. Q., Stark, A., Kheradpour, P., Kellis, M., Flicek, P., Chen, Y., Webber, C., Hardison, R., Nelson, J., Hallsworth-Pepin, K., Delehaunty, K., Markovic, C., Minx, P., Feng, Y. C., Kremitzki, C., Mitreva, M., Glasscock, J., Wylie, T., Wohldmann, P., Thiru, P., Nhan, M. N., Pohl, C. S., Smith, S. M., Hou, S. F., Renfree, M. B., Mardis, E. R. and Wilson, R. K. (2008) Genome analysis of the platypus reveals unique signatures of evolution. Nature, 453 7192: 175-183. doi:10.1038/nature06936


Author Warren, W. C.
Hillier, L. W.
Graves, J. A. M.
Birney, E.
Ponting, C. P.
Grutzner, F.
Belov, K.
Miller, W.
Clarke, L.
Chinwalla, A. T.
Yang, S. P.
Heger, A.
Locke, D. P.
Miethke, P.
Waters, P. D.
Veyrunes, F.
Fulton, L.
Fulton, B.
Graves, T.
Wallis, J.
Puente, X. S.
Lopez-Otin, C.
Ordonez, G. R.
Eichler, E. E.
Chen, L.
Cheng, Z.
Deakin, J. E.
Alsop, A.
Thompson, K.
Kirby, P.
Papenfuss, A. T.
Wakefield, M. J.
Olender, T.
Lancet, D.
Huttley, G. A.
Smit, A. F. A.
Pask, A.
Temple-Smith, P.
Batzer, M. A.
Walker, J. A.
Konkel, M. K.
Harris, R. S.
Whittington, C. M.
Wong, E. S. W.
Gemmell, N. J.
Buschiazzo, E.
Jentzsch, I. M. V.
Merkel, A.
Schmitz, J.
Zemann, A.
Churakov, G.
Kriegs, J. O.
Brosius, J.
Murchison, E. P.
Sachidanandam, R.
Smith, C.
Hannon, G. J.
Tsend-Ayush, E.
McMillan, D.
Attenborough, R.
Rens, W.
Ferguson-Smith, M.
Lefevre, C. M.
Sharp, J. A.
Nicholas, K. R.
Ray, D. A.
Kube, M.
Reinhardt, R.
Pringle, T. H.
Taylor, J.
Jones, R. C.
Nixon, B.
Dacheux, J. L.
Niwa, H.
Sekita, Y.
Huang, X. Q.
Stark, A.
Kheradpour, P.
Kellis, M.
Flicek, P.
Chen, Y.
Webber, C.
Hardison, R.
Nelson, J.
Hallsworth-Pepin, K.
Delehaunty, K.
Markovic, C.
Minx, P.
Feng, Y. C.
Kremitzki, C.
Mitreva, M.
Glasscock, J.
Wylie, T.
Wohldmann, P.
Thiru, P.
Nhan, M. N.
Pohl, C. S.
Smith, S. M.
Hou, S. F.
Renfree, M. B.
Mardis, E. R.
Wilson, R. K.
Title Genome analysis of the platypus reveals unique signatures of evolution
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
1476-4687
Publication date 2008-05-01
Sub-type Article (original research)
DOI 10.1038/nature06936
Open Access Status Not yet assessed
Volume 453
Issue 7192
Start page 175
End page 183
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non-protein-coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.
Keyword SMALL NUCLEOLAR RNAS
ORNITHORHYNCHUS-ANATINUS
ANTIMICROBIAL PEPTIDES
MONODELPHIS-DOMESTICA
PHYLOGENETIC ANALYSIS
VERTEBRATE EVOLUTION
DNA-SEQUENCES
IMMUNE-SYSTEM
GENE-CLUSTER
MONOTREME
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
 
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Created: Thu, 15 Mar 2012, 01:24:12 EST by Susan Allen on behalf of Institute for Molecular Bioscience