Candida pneumonia in patients with hematological neoplasia

Carvajal, Carlos, Rello, Jordi and Lipman, Jeffrey (2011). Candida pneumonia in patients with hematological neoplasia. In Elie Azoulay (Ed.), Pulmonary involvement in patients with hematological malignancies (pp. 349-356) Berlin, Germany: Springer - Verlag. doi:10.1007/978-3-642-15742-4_28


Author Carvajal, Carlos
Rello, Jordi
Lipman, Jeffrey
Title of chapter Candida pneumonia in patients with hematological neoplasia
Formatted title
Candida pneumonia in patients with hematological neoplasia
Title of book Pulmonary involvement in patients with hematological malignancies
Place of Publication Berlin, Germany
Publisher Springer - Verlag
Publication Year 2011
Sub-type Research book chapter (original research)
DOI 10.1007/978-3-642-15742-4_28
ISBN 9783642157417
3642157416
9783642157424
3642157424
Editor Elie Azoulay
Chapter number 28
Start page 349
End page 356
Total pages 8
Total chapters 73
Language eng
Formatted Abstract/Summary
Candida isolation from respiratory secretions rarely indicates invasive candidiasis and should not be treated with antifungal therapy. In contrast to pneumonia, colonization of the airway (or contamination of respiratory samples with oropharyngeal material) is extremely common. Whereas positive cultures from respiratory secretions are frequently used as indications to start antifungal therapy, multiple studies (including autopsies) consistently demonstrate poor predictive value at Candida isolation from lower respiratory secretions, including bronchoalveolar lavage (BAL). Diagnosis of Candida pneumonia requires histopathologic confirmation. Due to the extremely common finding of Candida in respiratory secretions, the lack of specificity (even using bronchoscopy) and the rarity of Candida pneumonia, a decision to treat with antifungal agents should never be based merely on respiratory tract cultures. Candida pneumonia (and lung abscess) is extremely uncommon.
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes xix, 827 p. : ill. ; 27 cm. Part IV: Lung Infections in Patients with HM.

Document type: Book Chapter
Collections: Official 2012 Collection
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Created: Wed, 14 Mar 2012, 03:42:14 EST by Sia Athanasas on behalf of Anaesthesiology and Critical Care - RBWH