Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring

Kesby, James P., O'Loan, Jonathan C., Alexander, Suzanne, Deng, Chao, Huang, Xu-Feng, McGrath, John J., Eyles, Darryl W. and Burne, Thomas H. J. (2012) Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring. Psychopharmacology, 220 3: 455-463. doi:10.1007/s00213-011-2492-0

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ269486_OA.pdf Full text (open access) application/pdf 437.99KB 0

Author Kesby, James P.
O'Loan, Jonathan C.
Alexander, Suzanne
Deng, Chao
Huang, Xu-Feng
McGrath, John J.
Eyles, Darryl W.
Burne, Thomas H. J.
Title Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring
Journal name Psychopharmacology   Check publisher's open access policy
ISSN 0033-3158
Publication date 2012-04-01
Year available 2011
Sub-type Article (original research)
DOI 10.1007/s00213-011-2492-0
Open Access Status File (Author Post-print)
Volume 220
Issue 3
Start page 455
End page 463
Total pages 9
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract
Rationale Developmental vitamin D (DVD) deficiency is a candidate risk factor for developing schizophrenia in humans. In rodents DVD deficiency induces subtle changes in the way the brain develops. This early developmental insult leads to select behavioural changes in the adult, such as an enhanced response to amphetamine-induced locomotion in female DVD-deficient rats but not in male DVDdeficient rats and an enhanced locomotor response to the Nmethyl-D-aspartate (NMDA) receptor antagonist, MK-801, in male DVD-deficient rats. However, the response to MK-801-induced locomotion in female DVD-deficient rats is unknown. Therefore, the aim of the current study was to further examine this behavioural finding in male and female rats and assess NMDA receptor density. Methods DVD-deficient Sprague Dawley rats were assessed for locomotion, ataxia, acoustic startle response (ASR) and prepulse inhibition (PPI) of the ASR to multiple doses of MK-801. The NMDA receptor density in relevant brain regions was assessed in a drug-naive cohort. Results DVD deficiency increased locomotion in response to MK-801 in both sexes. DVD-deficient rats also showed an enhanced ASR compared with control rats, but PPI was normal. Moreover, DVD deficiency decreased NMDA receptor density in the caudate putamen of both sexes. Conclusions These results suggest that a transient prenatal vitamin D  deficiency has a long-lasting effect on NMDA-mediated signalling in the rodent brain and may be a plausible candidate risk factor for schizophrenia and other neuropsychiatric disorders.
Keyword Schizophrenia
Vitamin D
Prepulse inhibition
Animal model
NMDA receptor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 21 September 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
School of Psychology Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 30 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 10 Mar 2012, 02:53:45 EST by Debra McMurtrie on behalf of Queensland Brain Institute