Vitamin D: A neurosteroid affecting brain development and function; implications for neurological and psychiatric disorders

Eyles, Darryl, Burne, Thomas and McGrath, John (2011). Vitamin D: A neurosteroid affecting brain development and function; implications for neurological and psychiatric disorders. In David Feldman, J. Wesley Pike and John S. Adams (Ed.), Vitamin D 3rd ed. (pp. 565-582) Amsterdam, The Netherlands: Academic Press. doi:10.1016/B978-0-12-381978-9.10032-0


Author Eyles, Darryl
Burne, Thomas
McGrath, John
Title of chapter Vitamin D: A neurosteroid affecting brain development and function; implications for neurological and psychiatric disorders
Language of Chapter Title eng
Title of book Vitamin D
Language of Book Title eng
Place of Publication Amsterdam, The Netherlands
Publisher Academic Press
Publication Year 2011
Sub-type Chapter in textbook
DOI 10.1016/B978-0-12-381978-9.10032-0
Edition 3rd
ISBN 9780123819789
0123819784
9780123819796
0123819792
Editor David Feldman
J. Wesley Pike
John S. Adams
Chapter number 32
Start page 565
End page 582
Total pages 18
Language eng
Abstract/Summary Vitamin D has been called the neglected neurosteroid. Vitamin D belongs to the super family of nuclear steroid transcription regulators that include thyroid hormones, vitamin A, androgens, and the glucocorticoids. As such vitamin D exerts its influence over a vast number of genes. All these agents have well-defined roles to play in shaping braindevelopment and ongoing function. Therefore it comes as some surprise to realize that neuroscientists have only recently directed their attention to this agent. In this review we have collated a diverse array of data describing how vitamin D signaling was established in the brain; how dietary, environmental, or genetically engineered abnormalities could affect braindevelopment and function; how vitamin D could be a neuroprotective agent and finally how a disturbance in normal vitamin-D-related activities could produce neurological or neuropsychiatric diseases. Given the substantial recent efforts of a number of laboratories in these endeavors it would appear that neurosteroid D has finally “arrived.”
Q-Index Code BX
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes First edition 1997; Second edition 2005

 
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Created: Tue, 06 Mar 2012, 22:52:34 EST by Dr Thomas Burne on behalf of Queensland Brain Institute