Cognitive effects of chemotherapy-induced menopause in breast cancer

Vearncombe, Katharine J., Rolfe, Margaret, Andrew, Brooke, Pachana, Nancy A., Wright, Margaret and Beadle, Geoffrey (2011) Cognitive effects of chemotherapy-induced menopause in breast cancer. The Clinical Neuropsychologist, 25 8: 1295-1313. doi:10.1080/13854046.2011.631586


Author Vearncombe, Katharine J.
Rolfe, Margaret
Andrew, Brooke
Pachana, Nancy A.
Wright, Margaret
Beadle, Geoffrey
Title Cognitive effects of chemotherapy-induced menopause in breast cancer
Journal name The Clinical Neuropsychologist   Check publisher's open access policy
ISSN 1385-4046
1744-4144
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1080/13854046.2011.631586
Open Access Status Not yet assessed
Volume 25
Issue 8
Start page 1295
End page 1313
Total pages 19
Place of publication Hove, E Sussex, U.K.
Publisher Psychology Press
Language eng
Abstract This study examined whether chemotherapy-induced menopause affects cognitive functioning in women with early breast cancer. The neuropsychological performance of 121 breast cancer patients (age M=9.62, SD=8.11, range=25.25-67.92) treated with chemotherapy was assessed pre-chemotherapy, as well as 1, 6, and 18 months post-chemotherapy completion. Linear mixed modeling was used to evaluate the data. Type of menopause (pre, chemotherapy-induced, and post menopause) was found to significantly interact with cognitive performance on two cognitive variables. Specifically, chemotherapy-induced menopausal women did not show any significant changes in performance on an abstract reasoning task, while the pre-menopausal and post-menopausal groups significantly improved over time. A significant interaction on a test of finger dexterity and coordination was also found, although inspection of the results indicated that this was due to a significant improvement in the pre-menopausal groups at 6 months post chemotherapy. After chemotherapy most cognitive variables showed improvements over time, although two indicators of verbal memory showed significant declines immediately after chemotherapy, with improvement by 18 months post completion. The current study found little evidence to suggest that chemotherapy-induced menopause broadly affects cognitive functioning after treatment administration. However, longer follow-up assessments are warranted to assess the long-term effects of combined chemotherapy and endocrine treatment.
Formatted abstract
This study examined whether chemotherapy-induced menopause affects cognitive functioning in women with early breast cancer. The neuropsychological performance of 121 breast cancer patients (age M = 49.62, SD = 8.11, range = 25.25–67.92) treated with chemotherapy was assessed pre-chemotherapy, as well as 1, 6, and 18 months post-chemotherapy completion. Linear mixed modeling was used to evaluate the data. Type of menopause (pre, chemotherapy-induced, and post menopause) was found to significantly interact with cognitive performance on two cognitive variables. Specifically, chemotherapy-induced menopausal women did not show any significant changes in performance on an abstract reasoning task, while the pre-menopausal and post-menopausal groups significantly improved over time. A significant interaction on a test of finger dexterity and coordination was also found, although inspection of the results indicated that this was due to a significant improvement in the pre-menopausal groups at 6 months post chemotherapy. After chemotherapy most cognitive variables showed improvements over time, although two indicators of verbal memory showed significant declines immediately after chemotherapy, with improvement by 18 months post completion. The current study found little evidence to suggest that chemotherapy-induced menopause broadly affects cognitive functioning after treatment administration. However, longer follow-up assessments are warranted to assess the long-term effects of combined chemotherapy and endocrine treatment.
Keyword Induced menopause
Neurotoxicity
Memory
Chemotherapy
Receiving adjuvant chemotherapy
Standard-dose chemotherapy
Functional assessment
Postmenopausal women
Replacement therapy
Follow-up
Estrogen
Symptoms
Fatigue
Multicenter
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 200320
406900
LPO669670
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Psychology Publications
 
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