Spontaneously obese dogs exhibit greater postprandial glucose, triglyceride, and insulin concentrations than lean dogs

Verkest, K. R., Rand, J. S., Fleeman, L. M. and Morton, J. M. (2012) Spontaneously obese dogs exhibit greater postprandial glucose, triglyceride, and insulin concentrations than lean dogs. Domestic Animal Endocrinology, 42 2: 103-112. doi:10.1016/j.domaniend.2011.10.002


Author Verkest, K. R.
Rand, J. S.
Fleeman, L. M.
Morton, J. M.
Title Spontaneously obese dogs exhibit greater postprandial glucose, triglyceride, and insulin concentrations than lean dogs
Journal name Domestic Animal Endocrinology   Check publisher's open access policy
ISSN 0739-7240
1879-0054
Publication date 2012-02-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.domaniend.2011.10.002
Open Access Status Not Open Access
Volume 42
Issue 2
Start page 103
End page 112
Total pages 10
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
Dogs do not appear to progress from obesity-induced insulin resistance to type 2 diabetes mellitus. Both postprandial hyperglycemia and postprandial hypertriglyceridemia have been proposed to cause or maintain beta cell failure and progression to type 2 diabetes mellitus in other species. Postprandialglucose, triglyceride, and insulinconcentrations have not been compared in lean and obesedogs. We measured serum glucose, triglyceride, and insulinconcentrations in nine naturally occurring obese and nine age- and gender-matched leandogs. After a 24-h fast, dogs were fed half their calculated daily energy requirement of a standardized diet that provided 37% and 40% of metabolizable energy as carbohydrate and fat, respectively. Fasting and postprandialglucose and triglycerideconcentrations were greater in the obesedogs (P < 0.001), although the mean insulinconcentration for this group was five times greater than that of the lean group (P < 0.001). Most of the 0.6 mM (11 mg/dL) difference in mean postprandialglucoseconcentrations between lean and obesedogs was attributable to a subset of persistently hyperglycemic obesedogs with mean postprandialglucoseconcentrations 1.0 mM (18 mg/dL) greater than that in leandogs. Persistently hyperglycemic obesedogs had lower triglyceride (P = 0.02 to 0.04) and insulin (P < 0.02) concentrations than other obesedogs. None of the dogs developed clinical signs of diabetes mellitus during follow-up for a median of 2.6 yr. We conclude that pancreatic beta cells in dogs are either not sensitive to toxicity because of mild hyperglycemia or lack another component of the pathophysiology of beta cell failure in type 2 diabetes mellitus.
Keyword Canine
Obesity
Metabolic syndrome
Hyperlipidemia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 10 November 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Veterinary Science Publications
 
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