HDAC inhibitors in parasitic diseases

Andrews, Katherine T., Haque, Ashraful and Jones, Malcolm K. (2012) HDAC inhibitors in parasitic diseases. Immunology and Cell Biology, 90 1: 66-77. doi:10.1038/icb.2011.97


Author Andrews, Katherine T.
Haque, Ashraful
Jones, Malcolm K.
Title HDAC inhibitors in parasitic diseases
Journal name Immunology and Cell Biology   Check publisher's open access policy
ISSN 0818-9641
1440-1711
Publication date 2012-01-01
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/icb.2011.97
Open Access Status DOI
Volume 90
Issue 1
Start page 66
End page 77
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 2403 Immunology
1307 Cell Biology
Abstract Parasitic diseases cause significant global morbidity and mortality, particularly in underdeveloped regions of the world. Malaria alone causes ~800 000 deaths each year, with children and pregnant women being at highest risk. There is no licensed vaccine available for any human parasitic disease and drug resistance is compromising the efficacy of many available anti-parasitic drugs. This is driving drug discovery research on new agents with novel modes of action. Histone deacetylase (HDAC) inhibitors are being investigated as drugs for a range of diseases, including cancers and infectious diseases such as HIV/AIDS, and several parasitic diseases. This review focuses on the current state of knowledge of HDAC inhibitors targeted to the major human parasitic diseases malaria, schistosomiasis, trypanosomiasis, toxoplasmosis and leishmaniasis. Insights are provided into the unique challenges that will need to be considered if HDAC inhibitors are to be progressed towards clinical development as potential new anti-parasitic drugs.
Keyword HDAC inhibitor
Malaria
Schistosomiasis
Leishmaniasis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 29 November 2011. SPECIAL FEATURE: Histone Deacetylases and their Inhibitors in Immunology.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Veterinary Science Publications
 
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