Central Projections of Sensory Neurons in the Drosophila Embryo Correlate with Sensory Modality, Soma Position, and Proneural Gene-Function

Merritt, DJ and Whitington, PM (1995) Central Projections of Sensory Neurons in the Drosophila Embryo Correlate with Sensory Modality, Soma Position, and Proneural Gene-Function. Journal of Neuroscience, 15 3: 1755-1767.

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Author Merritt, DJ
Whitington, PM
Title Central Projections of Sensory Neurons in the Drosophila Embryo Correlate with Sensory Modality, Soma Position, and Proneural Gene-Function
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 1995-03-01
Year available 1995
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 15
Issue 3
Start page 1755
End page 1767
Total pages 13
Place of publication CARY
Publisher OXFORD UNIV PRESS INC
Language eng
Abstract The peripheral nervous system (PNS) of the Drosophila embryo is especially suited for investigating the specification of neuronal identity: the PNS consists of a relatively simple but diverse set of individually identified sensory neurons; mutants, including embryonic lethals, can be readily generated and analyzed; and axon growth can potentially be followed from the earliest stages. We have developed a staining method to reveal the central projections of the full set of sensory neurons in the preterminal abdominal segments of the embryo. The sensory neurons exhibit modality-specific axonal projections in the CNS. The axons of external sense (es) organ neurons, primarily tactile in function, are restricted to a particular region within each neuromere and exhibit a somatotopic mapping within the CNS. The axons of stretch-receptive chordotonal (ch) organs project into a discrete longitudinal fascicle. Sensory neurons with multiple-branched dendrites (md neurons) project into a separate fascicle, A small number of md neurons have distinctive dorsal-projecting axonal processes in the CNS. A classification of sensory neurons based on their axon morphology correlates closely with the identity of the proneural gene responsible for their generation, suggesting that proneural genes play a central role in determining neuronal identity in the PNS of the embryo.
Keyword Sensory Afferent
Neural Development
Proneural Genes
Topographic Maps
Insect
Sense Organs
Neuronal Identity
Peripheral Nervous-System
Leg Movements
Manduca-Sexta
Receptive-Fields
Tactile Hairs
Organs
Insect
Neurogenesis
Locust
Melanogaster
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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