Does broad-spectrum beta-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria?

Nordmann, Patrice, Poirel, Laurent, Toleman, Mark A. and Walsh, Timothy R. (2011) Does broad-spectrum beta-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria?. Journal of Antimicrobial Chemotherapy, 66 4: 689-692. doi:10.1093/jac/dkq520

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Author Nordmann, Patrice
Poirel, Laurent
Toleman, Mark A.
Walsh, Timothy R.
Title Does broad-spectrum beta-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria?
Journal name Journal of Antimicrobial Chemotherapy   Check publisher's open access policy
ISSN 0305-7453
1460-2091
Publication date 2011-04-02
Sub-type Article (original research)
DOI 10.1093/jac/dkq520
Open Access Status Not yet assessed
Volume 66
Issue 4
Start page 689
End page 692
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
The NDM-1 gene, first identified in Sweden in 2008 in Klebsiella pneumoniae from a patient hospitalized in New Delhi, encodes a metallo-β-lactamase that inactivates all β-lactams except aztreonam. This blaNDM-1 gene has been identified in hospital- acquired bacterial species, such as K. pneumoniae, but also in the typical community- acquired species, Escherichia coli. This gene has been identified in strains that possess other resistance mechanisms contributing to their multidrug resistance patterns. It has been recently extensively reported from the UK, India and Pakistan and, albeit to a lesser extent, from a number of other countries worldwide. In most of the cases a link with the Indian subcontinent has also been established. To stem the onslaught of NDM producers, early identification of cases of NDM-related infections and prevention of their spread by implementing screening, hygiene measures and the isolation of carriers is needed.  
Keyword metallo-b-lactamases
carbapenemases
Enterobacteriaceae
India
Pakistan
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Non HERDC
 
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Citation counts: TR Web of Science Citation Count  Cited 157 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 174 times in Scopus Article | Citations
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Created: Tue, 31 Jan 2012, 21:20:43 EST by Roheen Gill on behalf of UQ Centre for Clinical Research