Rhabdovirus accessory genes

Walker, Peter J., Dietzgen, Ralf G., Joubert, D. Albert and Blasdell, Kim R. (2011) Rhabdovirus accessory genes. Virus Research, 162 1-2: 110-125. doi:10.1016/j.virusres.2011.09.004


Author Walker, Peter J.
Dietzgen, Ralf G.
Joubert, D. Albert
Blasdell, Kim R.
Title Rhabdovirus accessory genes
Journal name Virus Research   Check publisher's open access policy
ISSN 0168-1702
1872-7492
Publication date 2011-12-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.virusres.2011.09.004
Open Access Status DOI
Volume 162
Issue 1-2
Start page 110
End page 125
Total pages 16
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Subject 1306 Cancer Research
2725 Infectious Diseases
2406 Virology
Abstract The Rhabdoviridae is one of the most ecologically diverse families of RNA viruses with members infecting a wide range of organisms including placental mammals, marsupials, birds, reptiles, fish, insects and plants. The availability of complete nucleotide sequences for an increasing number of rhabdoviruses has revealed that their ecological diversity is reflected in the diversity and complexity of their genomes. The five canonical rhabdovirus structural protein genes (N, P, M, G and L) that are shared by all rhabdoviruses are overprinted, overlapped and interspersed with a multitude of novel and diverse accessory genes. Although not essential for replication in cell culture, several of these genes have been shown to have roles associated with pathogenesis and apoptosis in animals, and cell-to-cell movement in plants. Others appear to be secreted or have the characteristics of membrane-anchored glycoproteins or viroporins. However, most encode proteins of unknown function that are unrelated to any other known proteins. Understanding the roles of these accessory genes and the strategies by which rhabdoviruses use them to engage, divert and re-direct cellular processes will not only present opportunities to develop new anti-viral therapies but may also reveal aspects of cellar function that have broader significance in biology, agriculture and medicine.
Keyword Rhabdovirus
Accessory gene
Vesiculovirus
Ephemerovirus
Lyssavirus
Novirhabdovirus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
Queensland Alliance for Agriculture and Food Innovation
 
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