Cerebral white matter in early puberty is associated with luteinizing hormone concentrations

Peper, Jiska S., Brouwer, Rachel M., Schnack, Hugo G., van Baal, G. Caroline M., van Leeuwen, Marieke, van den Berg, Stéphanie M., de Waal, Henriëtte A. Delemarre-Van, Janke, Andrew L., Collins, D. Louis, Evans, Alan C., Boomsma, Dorret I., Kahn, René S. and Pol, Hilleke E. Hulshoff (2008) Cerebral white matter in early puberty is associated with luteinizing hormone concentrations. Psychoneuroendocrinology, 33 7: 909-915. doi:10.1016/j.psyneuen.2008.03.017

Author Peper, Jiska S.
Brouwer, Rachel M.
Schnack, Hugo G.
van Baal, G. Caroline M.
van Leeuwen, Marieke
van den Berg, Stéphanie M.
de Waal, Henriëtte A. Delemarre-Van
Janke, Andrew L.
Collins, D. Louis
Evans, Alan C.
Boomsma, Dorret I.
Kahn, René S.
Pol, Hilleke E. Hulshoff
Title Cerebral white matter in early puberty is associated with luteinizing hormone concentrations
Journal name Psychoneuroendocrinology   Check publisher's open access policy
ISSN 0306-4530
Publication date 2008-08-01
Sub-type Article (original research)
DOI 10.1016/j.psyneuen.2008.03.017
Volume 33
Issue 7
Start page 909
End page 915
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Pergamon
Language eng
Abstract Puberty is a period in which cerebral white matter grows considerably, whereas gray matter decreases. The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH). Here we investigated the phenotypic association between LH, global and focal gray and white matter in 104 healthy nine-year-old monozygotic and dizygotic twins. Volumetric MRI and voxel-based morphometry were applied to measure global gray and white matter and to estimate relative concentrations of regional cerebral gray and white matter, respectively. A possible common genetic origin of this association (genetic correlation) was examined. Results showed that higher LH levels are associated with a larger global white matter proportion and with higher regional white matter density. Areas of increased white matter density included the cingulum, middle temporal gyrus and splenium of the corpus callosum. No association between LH and global gray matter proportion or regional gray matter density was found. Our data indicate that a common genetic factor underlies the association between LH level and regional white matter density. We suggest that the increase of white matter growth during puberty reported earlier might be directly or indirectly mediated by LH production. In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence.
Keyword Brain structure
Luteinizing hormone
Voxel-based morphometry
White matter
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Tue, 24 Jan 2012, 20:14:12 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging