Biexponential diffusion decay in formalin-fixed prostate tissue: Preliminary findings

Bourne, Roger M., Kurniawan, Nyoman, Cowin, Gary, Stait-Gardner, Timothy, Sved, Paul, Watson, Geoffrey, Chowdhury, Supriya and Price, William S. (2012) Biexponential diffusion decay in formalin-fixed prostate tissue: Preliminary findings. Magnetic Resonance In Medicine, 68 3: 954-959. doi:10.1002/mrm.23291

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Author Bourne, Roger M.
Kurniawan, Nyoman
Cowin, Gary
Stait-Gardner, Timothy
Sved, Paul
Watson, Geoffrey
Chowdhury, Supriya
Price, William S.
Title Biexponential diffusion decay in formalin-fixed prostate tissue: Preliminary findings
Journal name Magnetic Resonance In Medicine   Check publisher's open access policy
ISSN 0740-3194
1522-2594
Publication date 2012-09-01
Year available 2011
Sub-type Article (original research)
DOI 10.1002/mrm.23291
Open Access Status File (Author Post-print)
Volume 68
Issue 3
Start page 954
End page 959
Total pages 6
Place of publication Hoboken, NJ, U.S.A.
Publisher John Wiley & Sons
Collection year 2013
Language eng
Formatted abstract
Magnetic resonance microimaging was used to measure diffusion decay over an extended b-factor range in a formalin-fixed normal prostate sample and a Gleason pattern 3+4 cancer tissue sample. The coefficients of biexponential fits to diffusion decay data from 1600 voxels of dimension 160 × 160 × 160 μm3 in each sample were correlated with underlying epithelial and stromal compartment partial volumes estimated from high-resolution apparent diffusion coefficient (ADC) data (40 × 40 × 40 μm3 voxels) from the same tissue. In the normal tissue sample, the signal fractions of the low and high ADC components of the biexponential fits correlated linearly with partial volumes of epithelial tissue (R2 = 0.6) and stromal tissue (R2 = 0.5), respectively. Similar but weaker correlations were observed in the cancer sample. Epithelium-containing high spatial resolution voxels appeared to be composed of ~60% low ADC and ~40% high ADC component. Stromal voxels appeared to be composed of ~20% low ADC and ~80% high ADC component. This preliminary report suggests that distinctly different diffusion properties in microscopically adjacent cell types contribute to the multiexponential diffusion decay phenomenon in prostate tissue.
Keyword Apparent diffusion coefficient
Diffusion decay
Prostate
Compartmentation
Biexponential
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 9 DEC 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Centre for Advanced Imaging Publications
 
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Created: Tue, 24 Jan 2012, 19:43:56 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging