SRY, sex determination and gonadal differentiation

Koopman, Peter and Wilhelm, Dagmar (2011). SRY, sex determination and gonadal differentiation. In Cheryll Tickle (Ed.), eLS eLS: Developmental Biology ed. (pp. 1-9) Chichester, U.K.: John Wiley & Sons. doi:10.1002/047001590X

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Author Koopman, Peter
Wilhelm, Dagmar
Title of chapter SRY, sex determination and gonadal differentiation
Title of book eLS
Place of Publication Chichester, U.K.
Publisher John Wiley & Sons
Publication Year 2011
Sub-type Research book chapter (original research)
DOI 10.1002/047001590X
Edition eLS: Developmental Biology
ISBN 9780470015902
Editor Cheryll Tickle
Start page 1
End page 9
Total pages 9
Language eng
Abstract/Summary The commitment to develop into a male or female embryo is dependent on whether testes or ovaries develop from the primordial gonads. This decision is in turn controlled by the function of a gene, SRY, found on the Y chromosome in mammals. The proper expression and function of SRY in supporting cell precursors induces a cascade of gene expression that causes these cells to differentiate into Sertoli cells. Subsequently, Sertoli cells orchestrate the development of all other cell types resulting in the formation of testes, which produce hormones required for other aspects of male development. In the absence of SRY, or if SRY function is impaired, the supporting cells differentiate into granulosa cells, ovaries form and the embryo develops as a female.
Keyword Sex determination
Sex reversal
Y chromosome
Testis development
Ovary development
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes eLS (formerly known as the Encyclopedia of Life Sciences) is a monthly-updating reference work containing over 4,800 specially commissioned, peer-reviewed and citable articles written by leaders in the field. It offers comprehensive and authoritative coverage of the life sciences for students, lecturers and researchers alike. Published Online: 15 NOV 2011

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Created: Wed, 18 Jan 2012, 21:03:53 EST by Susan Allen on behalf of Institute for Molecular Bioscience