SRY protein function in sex determination: Thinking outside the box

Zhao, Liang and Koopman, Peter (2012) SRY protein function in sex determination: Thinking outside the box. Chromosome Research, 20 1: 153-162. doi:10.1007/s10577-011-9256-x

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Author Zhao, Liang
Koopman, Peter
Title SRY protein function in sex determination: Thinking outside the box
Journal name Chromosome Research   Check publisher's open access policy
ISSN 0967-3849
Publication date 2012-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1007/s10577-011-9256-x
Open Access Status Not Open Access
Volume 20
Issue 1
Start page 153
End page 162
Total pages 10
Editor Tariq Ezaz
Jennifer Graves
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Language eng
Formatted abstract
Even though the mammalian sex-determining gene Sry has been intensively studied for the two decades since its discovery, the regions outside the conserved HMG box DNA-binding domain have received less attention due to a lack of sequence conservation and of obvious structural/functional motifs. Here, we summarize the available evidence for function beyond the HMG box, identify the known and postulated biochemical functions of the non-HMG-box domains in sex determination, and present possible explanations for the puzzling diversity of these non-HMG-box domains.
Keyword SRY
Non-HMG-box domains
Sex determination
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 08 December 2011. From the issue entitled "Special issue on Sex and Sex Chromosomes - New Clues from Non-Model Species."

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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Created: Wed, 18 Jan 2012, 20:33:37 EST by Susan Allen on behalf of Institute for Molecular Bioscience