Male sex determination: Insights into molecular mechanisms

McClelland, Kathryn, Bowles, Josephine and Koopman, Peter (2012) Male sex determination: Insights into molecular mechanisms. Asian Journal of Andrology, 14 1: 164-171. doi:10.1038/aja.2011.169


Author McClelland, Kathryn
Bowles, Josephine
Koopman, Peter
Title Male sex determination: Insights into molecular mechanisms
Journal name Asian Journal of Andrology   Check publisher's open access policy
ISSN 1008-682X
1745-7262
Publication date 2012-01-01
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/aja.2011.169
Open Access Status DOI
Volume 14
Issue 1
Start page 164
End page 171
Total pages 8
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Abstract Disorders of sex development often arise from anomalies in the molecular or cellular networks that guide the differentiation of the embryonic gonad into either a testis or an ovary, two functionally distinct organs. The activation of the Y-linked gene Sry (sex-determining region Y) and its downstream target Sox9 (Sry box-containing gene 9) triggers testis differentiation by stimulating the differentiation of Sertoli cells, which then direct testis morphogenesis. Once engaged, a genetic pathway promotes the testis development while actively suppressing genes involved in ovarian development. This review focuses on the events of testis determination and the struggle to maintain male fate in the face of antagonistic pressure from the underlying female programme. Asian Journal of Andrology (2012) 14, 164-171; doi: 10.1038/aja.2011.169; published online 19 December 2011
Formatted abstract
Disorders of sex development often arise from anomalies in the molecular or cellular networks that guide the differentiation of the embryonic gonad into either a testis or an ovary, two functionally distinct organs. The activation of the Y-linked gene Sry (sex-determining region Y) and its downstream target Sox9 (Sry box-containing gene 9) triggers testis differentiation by stimulating the differentiation of Sertoli cells, which then direct testis morphogenesis. Once engaged, a genetic pathway promotes the testis development while actively suppressing genes involved in ovarian development. This review focuses on the events of testis determination and the struggle to maintain male fate in the face of antagonistic pressure from the underlying female programme.
Keyword Gonadal
Knockout
Mice
Sex determination
Sex-determining region Y protein
Sex disorders
Sex reversal
Sexual development
Testis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 19 December 2011

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 18 Jan 2012, 20:27:24 EST by Susan Allen on behalf of Institute for Molecular Bioscience