Initiating meiosis: The case for retinoic acid

Griswold, Michael D., Hogarth, Cathryn A., Bowles, Josephine and Koopman, Peter A. (2012) Initiating meiosis: The case for retinoic acid. Biology of Reproduction, 86 2: 35.1-35.7. doi:10.1095/biolreprod.111.096610

Author Griswold, Michael D.
Hogarth, Cathryn A.
Bowles, Josephine
Koopman, Peter A.
Title Initiating meiosis: The case for retinoic acid
Journal name Biology of Reproduction   Check publisher's open access policy
ISSN 0006-3363
Publication date 2012-02-01
Year available 2011
Sub-type Article (original research)
DOI 10.1095/biolreprod.111.096610
Open Access Status Not yet assessed
Volume 86
Issue 2
Start page 35.1
End page 35.7
Total pages 7
Place of publication Madison, WI, United States
Publisher Society for the Study of Reproduction
Language eng
Abstract The requirement for vitamin A in reproduction and development was first determined from studies of nutritional deficiencies. Subsequent research has shown that embryonic development and both male and female reproduction are modulated by retinoic acid (RA), the active form of vitamin A. Because RA is active in multiple developmental systems, its synthesis, transport, and degradation are tightly regulated in different tissues. A growing body of evidence implicates RA as a requirement for the initiation of meiosis in both male and female mammals, resulting in a mechanistic model involving the interplay of RA, RA synthesis enzymes, RA receptors, and degradative cytochrome P450 enzymes in this system. Recently, that model has been challenged, prompting a review of the established paradigm. While it remains possible that additional molecules may be involved in regulating entry into meiosis, the weight of evidence supporting a key role for RA is incontrovertible.
Keyword Germ cells
Retinoic acid
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID U54 42454
HD 10808
Institutional Status UQ
Additional Notes Published online before print November 9, 2011. Article # 35.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
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Created: Wed, 18 Jan 2012, 20:12:54 EST by Susan Allen on behalf of Institute for Molecular Bioscience