The transcriptional control of lymphatic vascular development

Francois, Mathias, Harvey, Natasha L. and Hogan, Benjamin M. (2011) The transcriptional control of lymphatic vascular development. Physiology, 26 3: 146-155. doi:10.1152/physiol.00053.2010


Author Francois, Mathias
Harvey, Natasha L.
Hogan, Benjamin M.
Title The transcriptional control of lymphatic vascular development
Journal name Physiology   Check publisher's open access policy
ISSN 1548-9213
1548-9221
Publication date 2011-06-01
Year available 2011
Sub-type Article (original research)
DOI 10.1152/physiol.00053.2010
Open Access Status Not yet assessed
Volume 26
Issue 3
Start page 146
End page 155
Total pages 10
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Subject 1314 Physiology
Abstract More than 100 years ago, Florence Sabin suggested that lymphatic vessels develop by sprouting from preexisting blood vessels, but it is only over the past decade that the molecular mechanisms underpinning lymphatic vascular development have begun to be elucidated. Genetic manipulations in mice have identified a transcriptional hub comprised of Prox1, CoupTFII, and Sox18 that is essential for lymphatic endothelial cell fate specification. Recent work has identified a number of additional transcription factors that regulate later stages of lymphatic vessel differentiation and maturation. This review highlights recent advances in our understanding of the transcriptional control of lymphatic vascular development and reflects on efforts to better understand the activities of transcriptional networks during this discrete developmental process. Finally, we highlight the transcription factors associated with human lymphatic vascular disorders, demonstrating the importance of understanding how the activity of these key molecules is regulated, with a view toward the development of innovative therapeutic avenues.
Keyword Physiology
Physiology
PHYSIOLOGY
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 626959
1011242
FT100100165
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 17 Jan 2012, 23:19:25 EST by Susan Allen on behalf of Institute for Molecular Bioscience