Review of case reports of inadvertent intrathecal administration of vincristine: Recommendations to reduce occurrence

Gilbar, Peter J. and Dooley, Michael J. (2007) Review of case reports of inadvertent intrathecal administration of vincristine: Recommendations to reduce occurrence. Asia-Pacific Journal of Clinical Oncology, 3 2: 59-65. doi:10.1111/j.1743-7563.2007.00097.x


Author Gilbar, Peter J.
Dooley, Michael J.
Title Review of case reports of inadvertent intrathecal administration of vincristine: Recommendations to reduce occurrence
Journal name Asia-Pacific Journal of Clinical Oncology   Check publisher's open access policy
ISSN 1743-7555
1743-7563
Publication date 2007-06-01
Year available 2007
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1743-7563.2007.00097.x
Open Access Status Not Open Access
Volume 3
Issue 2
Start page 59
End page 65
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Vincristine has been in clinical use for over 40 years with initial publication of the results from successful trials in 1962. Catastrophic neurotoxicity has been associated with the administration of vincristine directly into the cerebrospinal fluid (CSF). Since the first case in 1968 there have been numerous other instances, of which 23 have been reported in the literature. Of these cases 18 resulted in death. The most prominent damage on autopsy was generally in the spinal cord, brain stem and cerebellum, with severity tending to be greater in the neurons adjacent to the CSF. Fatalities appeared due to a progressive ascending myeloencephalopathy. Early recognition and immediate treatment with CSF drainage and intrathecal exchange appears to be the only intervention that has improved patient survival. The volume of injection, dose and time from the incident until the ventriculo-lumbar washout appear critical, as these factors might contribute to the extent of drug distribution in the CNS. Although several antidotes for vincristine have been suggested, including folinic acid and glutamic acid, supportive evidence for their effectiveness is scant. Several recommendations regarding prevention of this catastrophic event have been proposed.
Keyword Administration
Intrathecal
Neurotoxicity
Vincristine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: ERA 2012 Admin Only
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